The Yamada laboratory studies the mechanisms of the trafficking of signaling molecules, such as the receptor for the growth factor, which regulates angiogenesis and vascular leakage. The regulation of receptor trafficking is a novel concept for angiogenesis-related and vascular-leakage-related diseases such as cancer growth, cancer metastasis, and eye diseases (diabetic retinopathy and wet AMD). Using mouse models, cell biology, and molecular biology techniques, we are defining the mechanisms of pathological angiogenesis and vascular leakage in these diseases.

Duties & Responsibilities