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Characterization of mRNA export pathways in protozoan parasites Trypanosoma brucei and Trypanosoma cruzi.
To conduct experimental procedures as part of ongoing research projects geared towards understanding mRNA processing and export in trypanosomes, protozoan parasites responsible for Sleeping Sickness in Africa and Chagas disease in the Americas. Collect, verify and record data, compile information in support of research. Will report to a senior research scientist in the Obado laboratory.
The central dogma of molecular biology highlights the simple flow of genetic information, that DNA is transcribed into RNA which is exported out of the nucleus and translated into protein in the cytoplasm. Several components of the transcription-export complex in trypanosomes are cryptic and unknown. Furthermore, RNA export pathway in trypanosomes is evolutionarily divergent from those of its vertebrate hosts as evidenced by the composition and architecture of the trypanosome nuclear pore complex (NPC). Work in Dr. Obado’s laboratory focuses on uncovering key components of the mRNA export pathway and determining the structure function relationships between nucleocytoplasmic transport and the divergent trypanosome NPC.
Required Education/Experience:
Required Credentials:
Preferred:
This compensation range was calculated based on full-time employment (2080 hours worked per calendar year). Offers are determined by multiple factors including equity, skills, experience, and expertise, and may vary within the range provided.
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Full Time
$53k-71k (estimate)
02/11/2023
04/21/2024
seattlechildre...
Seattle, WA
<25
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