Role Summary:

The Program Team Leader (PTL) is a passionate drug developer with a global perspective, who brings adaptable leadership, strategic product development acumen, and relentless pursuit of long-term success for patients and Dyne’s medicines. The PTL is a highly visible leadership role. Working with an experienced Program Manager and a cross-functional team, the PTL shapes the Program strategy, goals, priorities, and plans, bringing both a ‘future-orientation’ toward the ultimate goal of broad, global commercial access for patients in need, and a “pragmatic-orientation” to chart the path, mitigate risks, cultivate options, and lead through complex drug development decisions.

This role is based in Waltham, MA without the possibility of being a remote role. 

Primary Responsibilities Include:

• Lead a high-performing cross-functional Program Team, focusing on both the “what”, such as strategy, priorities, output, and resources, and also the “how”, such as maintaining a fulfilling, collaborative, and sustainable team environment
• Establish a robust and well-understood Program strategy for bringing a life-changing medicine to patients in need
• Ensure that research, non-clinical, clinical, regulatory, CMC, and commercial strategies and plans are aligned with the overall Program strategy
• Structure and facilitate critical cross-functional decisions within Program Team and senior leadership team, bringing all relevant perspectives to bear while driving to efficient decisions in a fast-paced environment
• Own Program recommendations across stages of the Program to achieve milestones and timelines
• Drive preparation and presentation of materials for Board of Directors and Scientific Advisory Board
• Maintain clear, open, and proactive communication with the senior leadership team and other stakeholders regarding Program strategy, status, priorities, risks and needs, and facilitate appropriate decision-making
• Keep abreast of emerging developments regarding research and development in the fields of muscle diseases and oligonucleotide drug discovery and development
• Build visible, constructive, and credible presence within KOL and patient community for relevant disease areas
• Participate in business development activities, as needed, including opportunity evaluations and due diligence
• Provide a motivating leadership example within Dyne more broadly during periods of rapid growth
• Responsibly steward the Program budget in collaboration with finance and functional leaders
• Foster a culture of collaboration, innovation, discovery, and cutting-edge research focused on scientific excellence, open communication, and continual improvement
• Actively coach team members to achieve their best and support to mitigate gaps in skill or capacity
• Consider needs of the Program in context of Dyne corporate strategy and priorities, as primary advocate for the Program among Dyne senior leadership
• Lead with Dyne’s core values at the forefront

Education and Skills Requirements

• Experience in Phase 1-3 drug development is required; product launch/early commercialization experience a strong plus
• Proven and respected leader with:
  • Advanced degree in Medical or Life Science, MD, PhD or MBA or equivalent
  • 12 years of experience in pharmaceutical industry in leadership positions in drug development and proven track record in driving Programs through IND, early clinical, pivotal stages and approval
  • And/or at least 12 years in pharmaceutical industry in significant development and/or commercial leadership or general management positions including working with development teams in cross-functional setting, with exceptional track record of delivering on business objectives, activity/milestones leading to filing and launching, and strong knowledge of neuromuscular diseases
  • Experience in rare genetic diseases preferred
• Other key traits:
• Entrepreneurial team leader, able to shape and communicate the vision for an important therapeutic Program and guiding the development of the product strategy and its execution
• Insightful people leader supporting and coaching high-caliber functional experts to achieve their absolute best
• Collaborative corporate leader partnering with other senior leaders to shape and fulfil Dyne’s overall mission to develop and commercialize transformational therapeutics for people living with serious diseases
• Orientation towards collective achievement and team credit, combined with individual sense of responsibility and accountability for teamwork and product
• Adept at leading through ambiguity and provide steadiness and consistency among shifting priorities
• Comfortable with fast-paced and nimble organizational environment
• Demonstrated experience in building highly effective and motivated cross-functional teams and in guiding teams and organizations in making complex and high-stakes data-driven decisions
• Proven acumen for cross-functional leadership and influencing without direct authority, both among cross-functional team members and senior functional leaders
• Demonstrated scientific knowledge and curiosity necessary for thought partnership across all functions
• Proven ability to establish and maintain credible and trust-based relationships with external stakeholders (e.g., KOLs, patient advocacy groups, regulators or investors)
• Outstanding sense of urgency and ability to pace the team’s work to achieve milestone achievement in highly competitive landscape
• Excellent communication skills (verbal, written, presentation) and ability to clearly communicate complex ideas stakeholders and teams at all levels
• Natural focus on team dynamics and proven ability to coach and support team members to perform at their best
• Effective people-oriented collaboration skills in an environment with cross internal functional teams, and third-party collaborators/vendors
• Team player and mentor, who listens effectively and invites response and discussion
• Collaborator who communicates in an open, clear, complete, timely and consistent manner

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