Equipment Engineer - Downstream Operations

Piper Companies is seeking an Equipment Engineer - Downstream Operations role to join a growing leader in the pharmaceutical/biotechnology space for a contract, onsite position located in Holly Springs, NC. The Equipment Engineer - Downstream Operations will support downstream manufacturing operations by ensuring equipment readiness, troubleshooting issues, and coordinating cross-functional projects to maintain efficient and compliant production processes.

Responsibilities of the Equipment Engineer - Downstream Operations include:

• Ensure equipment readiness and troubleshoot issues for downstream operations including chromatography, UF/DF (ultrafiltration/diafiltration), and buffer preparation.
• Provide on-the-floor support to manufacturing teams to maintain smooth and efficient operations.
• Collaborate with cross-functional teams including manufacturing, automation, and maintenance to coordinate equipment-related projects.
• Lead efforts to transition equipment from project phase into full-scale manufacturing operations.
• Support flexible work schedules, including occasional nights and weekends, to meet production needs.
  
  

Qualifications for the Equipment Engineer - Downstream Operations include:

• Minimum 5 years of hands-on experience in downstream operations, specifically with chromatography, UF/DF, and buffer preparation.
• Demonstrated ability to move equipment from project phase into operational manufacturing environments (not lab-based).
• Bachelor’s degree in Chemical, Industrial, or Mechanical Engineering (preferred).
• Strong problem-solving skills and ability to work effectively in a cross-functional team within a GMP manufacturing setting.
  
  

Compensation for the Equipment Engineer - Downstream Operations:

• Salary Range: $135,000-$150,000/year
• Comprehensive Benefits: Medical, Dental, Vision, sick leave if required by law, and 401K
  
  

This job opens for applications on 9/19/25. Applications for this job will be accepted for at least 30 days from the posting date.

Keywords: equipment engineer, downstream operations, chromatography, UF/DF, ultrafiltration, diafiltration, buffer preparation, GMP manufacturing, biopharmaceutical, process engineering, chemical engineering, industrial engineering, mechanical engineering, equipment troubleshooting, manufacturing support, project coordination, automation systems, maintenance coordination, equipment commissioning, biotech manufacturing, cleanroom operations, process validation, equipment lifecycle, on-the-floor support