What are the responsibilities and job description for the Downstream Equipment Engineer position at Piper Companies?
Piper Companies is seeking a Downstream Equipment Engineer for a rapidly growing biomanufacturing organization located in Cary, North Carolina (NC). The Downstream Equipment Engineer will support startup and transition of downstream equipment into GMP manufacturing. This will be an on-site position based out of Holly Springs, NC.
Responsibilities of the Downstream Equipment Engineer:
- Support startup and commissioning of downstream equipment (chromatography, UF/DF, buffer prep)
- Ensure equipment readiness and smooth transition into GMP manufacturing
- Collaborate cross-functionally to troubleshoot and optimize startup processes
- Execute final equipment verifications and partner with QA, Automation, and Maintenance
- Provide hands-on support during initial production runs and documentation
- Contribute to continuous improvement and coordinate with a 15-person operations team
Qualifications for the Downstream Equipment Engineer:
- 5 years of hands-on experience in downstream operations including chromatography, UF/DF, and buffer preparation
- Proven track record of transitioning equipment from project phase to full-scale manufacturing operations
- Strong understanding of GMP environments and large-scale bioprocessing systems
- Demonstrated ability to troubleshoot and optimize purification processes in a production setting
- Bachelor’s degree in Chemical, Industrial, or Mechanical Engineering (preferred)
Compensation for the Downstream Equipment Engineer:
- Salary Range: $125,000-$149,000/year
- Comprehensive Benefits: Sick leave if required by law, medical, dental, vision, 401K
This job opens for applications on 09/15/2025. Applications for this job will be accepted for at least 30 days from the posting date.
Keywords: Downstream processing, equipment engineer, process engineer, downstream process engineer, chromatography, UF/DF, buffer preparation, GMP manufacturing, equipment startup, commissioning, process optimization, troubleshooting, CQV, equipment readiness, bioprocessing, chemical engineering, industrial engineering, mechanical engineering, cross-functional collaboration, continuous improvement, production support
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Salary : $125,000 - $149,000
