MES Engineer

Role Overview

We are seeking an MES Engineer with a strong testing mindset and hands-on Emerson Syncade experience to support a large pharmaceutical expansion in the Raleigh–Durham area. This role is highly execution-focused and ideal for someone who thrives in dynamic manufacturing environments, can quickly learn new processes, and excels at validating MES configurations, calculations, and workflows in support of tech transfer and paperless manufacturing initiatives.

The engineer will play a key role in supporting Syncade MES configuration and testing across two drug substance manufacturing facilities, working closely with Automation, Manufacturing, Quality, CSV, and CQV teams to ensure systems are robust, compliant, and ready to support new products and downstream operations.

Key Responsibilities

MES Configuration & Support

• Support the design, configuration, and implementation of an Emerson Syncade Manufacturing Execution System to enable paperless manufacturing with full ERP/MES/DCS integration.
• Implement and troubleshoot MES configuration changes across DeltaV DCS, DeltaV MES (Syncade), and a custom formula/parameter management system.
• Debug configuration items and system behaviors within Syncade, ensuring issues are properly triaged to the correct teams and resolved without impacting manufacturing execution.
• Migrate solution components between Syncade environments (e.g., development, test, and production).

MES Testing & Validation (Primary Focus)

• Translate functional and technical requirements into detailed MES test protocols.
• Execute MES testing across a large volume of documents and system objects, including:
• Library objects
• Calculations and parameter setups
• Recipes and workflows
• Electronic Batch Records (EBR)
• Design and execute testing strategies for rapidly evolving or dynamically developed configurations and code.
• Support infrastructure setup, software installation, recipe development, and User Acceptance Testing (UAT) in partnership with end users.
• Support tech transfer activities by identifying gaps between source and target processes, particularly as global processes are transferred and localized (e.g., Denmark → US).

Manufacturing & Tech Transfer Support

• Support technical runs and process execution for both established and new downstream manufacturing operations.
• Troubleshoot MES-related issues during execution, identifying whether problems stem from process design, system configuration, or operational use.
• Ensure MES workflows do not inadvertently constrain or embed inaccurate manufacturing processes during tech transfer or scale-up activities.