JOB SUMMARY:

Responsible for designing and conducting research studies to support our drug discovery programs, including target validation, structure-activity relationship assessment, biomarker discovery, and mechanism of action studies. In addition, evaluates the effects of novel compounds in cancer models (in vitro & in vivo). Hands on, laboratory focused role.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Maintain cancer cell lines and establish stable/drug resistant cell lines.
• Perform semi high-throughput assays and prepare/maintain necessary assay reagents.
• Participate in target validation.
• Develop and conduct various cell-based assays to characterize potency of drug candidates.
• Develop and validate new assays & technologies.
• Develop other molecular biology-based assays using techniques such as cloning, DNA/RNA/protein extraction and RT-PCR.
• Analyze, interpret, and generate data reports in a timely manner.
• Troubleshoot complex assays.
• Other projects and assignments as required.

EDUCATION/KNOWLEDGE/SKILLS/ABILITIES REQUIRED:

• BS/MS with 5-8 years of experience (pharmaceutical/biotech industry)
• Knowledge of cancer biology, signal transduction pathways and transcription regulation.
• Hands-on experience with cancer cell culture and cell-based assays with a variety of readout technologies in low, medium, and high throughput. Experience in spheroid /organoid culture is desirable.
• Experience with cell genetic manipulation techniques, such as siRNA, shRNA, and CRISPR is desirable.
• Highly experienced in protein assay development such as western blot/JESS, flow cytometry, ELISA, AlphaLisa, and immunoprecipitation.
• Experienced in cellular viability assays, and molecular biology techniques, such as cloning and qPCR.
• In-depth experience of how to use basic software for data analysis (e.g., Prism, Microsoft Excel) and generating reports (PowerPoint).
• Ability to work independently, multi-task, and prioritize daily activities.
• High attention to detail.
• Demonstrates a high level of accuracy and effective oral and written communication skills.
• Flexibility within a rapidly changing environment.
• Excellent ability to work in a goal and team-oriented setting.
• Well-developed organizational skills.