At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson's disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *in collaboration with AbbVie

About the Role:

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• Designs and performs experiments to support scientific activities and project goals involving cell and biochemical assays

• Recommends alternatives, researches new methods and techniques and may proactively seek out senior personnel and outside experts to discuss potential solutions to problems

• Generates and works with complex bioinformatic data sets, with a strong understanding of advanced data analysis and statistical tests

• Responsible for advanced cell based assay development, including primary cells and tissues

• Maintains and updates SOP's and writes data summaries for experiments conducted

• Handles and doses animals in a laboratory setting

• Reviews, comprehends and complies with all SOP's, and safety and quality assurance standards at all times

• Provides training and/or supervision to junior staff, as needed

• Gene Therapy specific work will include work on Gene Therapy projects from inception to IND-enabling studies. Works with internal colleagues and external collaborators across all disciplines of R&D to select targets and develop Gene Therapy products. Designs in vitro and in vivo strategies for development of Gene Therapies and conduct and/or manage in vitro and in vivo studies to measure potency and efficacy. Monitors the latest developments in the Gene Therapy space for opportunities to in-license or acquire technologies. Prepares detailed data reports and present results to peers, colleagues, and collaborators. Presents data as appropriate at scientific meetings at the National and International level

• Other duties as assigned

• BS/BA degree and 5 years of relevant experience OR

• MS/MA degree and 3 years of relevant experience OR

• PhD or equivalent and some relevant experience; may include postdoc experience, Gene Therapy positions will require a PhD in Pharmacology, Neuroscience, Endocrinology, Physiology, or closely related discipline

• Gene Therapy position will require a minimum of 4 years of postdoctoral experience in gene therapy, or 2 years in the biopharmaceutical industry

• Advanced tissue culture techniques, including knowledge of iPSC and precursor cell handling and differentiation

• Working knowledge of NGS technologies, their implementation, and data analysis & relevant statistical tests

• Gene manipulation techniques, including cloning, and use of gene expression manipulation technologies (ASO, siRNA, miRNA, AAV transduction)

• Tissue handling techniques for detection of gene and protein expression, including fixation, sectioning, IHC, histological staining, ISH

• Demonstrates solid level of understanding project / group goals and methods

• Consistently recognizes anomalous and inconsistent results and interprets experimental outcomes

• Able to explain the process behind the data and implications of the results

• Strong knowledge of one or more scientific disciplines, becoming expert in one discipline.

• Strong knowledge of scientific principles, methods and techniques

• Strong knowledge and demonstrated ability working with a variety of laboratory equipment/tools.

• Ability to work as part of a team; may train lower levels

• Excellent computer skills

• Strong communications, problem-solving, analytical thinking skills

• Detail oriented yet can see broader picture of scientific impact on team

• Ability to meet multiple deadlines, with a high degree of accuracy and efficiency

• Strong project management skills

Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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