The Postdoctoral Research Associate is responsible for conducting research in the Laganowsky laboratory to better understand how lipids modulate the structure and function of membrane proteins. The candidate will be use advanced ion mobility mass spectrometry technology for studying intact protein complexes to accelerate biological and drug discoveries, and therapeutic development through leading edge research and development and analysis. These studies will be complemented with structural studies using X-ray crystallography/cryoEM and in conjunction with standard biochemical approaches.The Postdoctoral Research Associate will also express and purify proteins using a variety of expression systems, ranging from bacteria, insect cells, to HEK293. The scientist will assist the Principle Investigator by organizing and conducting cutting-edge experiments to investigate membrane protein lipid interactions on the molecular level. Selected publications from the laboratory are listed below:

Zhu Y, Schrecke S, Tang S, Odenkirk MT, Walker T, Stover L, Lyu J, Zhang T, Russell D, Baker ES, Yan X, Laganowsky A. Cupric Ions Selectively Modulate TRAAK-Phosphatidylserine Interactions. JACS. 2022 Apr 27;144(16):7048-7053. doi: 10.1021/jacs.2c00612.

Schrecke S, Zhu Y, McCabe JW, Bartz M, Packianathan C, Zhao M, Zhou M, Russell D, Laganowsky A. Selective regulation of human TRAAK channels by biologically active phospholipids. Nat Chem Biol. 2021 Jan;17(1):89-95. doi: 10.1038/s41589-020-00659-5.

Liu Y, LoCaste CE, Liu W, Poltash ML, Russell DH, Laganowsky A. Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel. Nat Commun. 2019 Mar 22;10(1):1352. doi: 10.1038/s41467-019-09333-4.

Patrick JW, Boone CD, Liu W, Conover GM, Liu Y, Cong X, Laganowsky A. Allostery revealed within lipid binding events to membrane proteins. PNAS. 2018 Mar 20;115(12):2976-2981. doi: 10.1073/pnas.1719813115.

Cong X, Liu Y, Liu W, Liang X, Laganowsky A. Allosteric modulation of protein-protein interactions by individual lipid binding events. Nat Commun. 2017 Dec 19;8(1):2203. doi: 10.1038/s41467-017-02397-0.

Job Type: Full-time

Pay: $45,000.00 - $60,000.00 per year

Benefits:

• Dental insurance
• Health insurance
• Paid time off
• Vision insurance

Schedule:

• Choose your own hours

Education:

• Doctorate (Required)

Experience:

• Molecular biology: 1 year (Preferred)

Work Location: In person