Principal Scientist/Associate Director, Translational and Biomarker Research

Immunitas: the human approach to oncology

We are developing targeted therapeutics for patients with challenging, complex cancers. We employ
a single-cell sequencing platform to dissect the biology of immune cells in human tumors and
identify exciting, novel oncology targets. We are currently advancing multiple programs toward early
human clinical studies.

We are a small, vibrant team looking for researchers who:

• want to see the direct impact of their work
• are proactive and thoughtful
• work well in a close environment at a rapid pace
• bring “can-do” problem solving to work every day
• get things done

Position Summary

Immunitas is seeking a highly skilled and engaged scientist with leadership experience and expertise
in translational and biomarker research, preferably with immunotherapy experience, to join our
growing team. This individual will help shape and execute the translational and biomarker strategy
across the preclinical and clinical portfolio. The successful candidate will guide translational and
biomarker studies to confirm/generate mechanistic insights and demonstrate target engagement/PD
effects of Immunitas therapeutic agents. He/She will ideally have proven success in building strong
translational data packages supporting INDs, defining biomarker strategies for preclinical/clinical
candidate stage programs, and implementing translational and biomarker programs in clinical trials.

Responsibilities will include:

• Work closely with discovery and clinical teams to develop translational hypotheses, design

and implement translational studies to generate data supporting INDs, as well as leading the
design and generation of clinic-ready biomarker assays

• Define and implement strategies for translational studies and biomarker assays using

preclinical models and patient samples to define PK/PD/efficacy relationships, patient
selection/enrichment plans and combination approaches

• Oversee internal teams, external vendors/CROs and collaborators to develop, qualify,

transfer, and validate relevant biomarker assays to support development programs across
Immunitas’ pipeline

• Perform and support clinical trial biomarker data analysis and interpretation to correlate

biological response with clinical outcome and enable evaluation of proof of mechanism and
proof of concept

• Manage, mentor and develop translational and biomarker research team members
• Develop productive, collaborative relationships with cross-functional colleagues in Discovery

Biology and Pharmacology, Computational Biology, Molecular Biology and Protein Science,
Antibody Discovery, and Clinical Development

• Ensure delivery of agreed project milestones and timely communication of goals and

deliverables

• Review and optimize existing processes to ensure best practice of preclinical and clinical

translational activities

• Author and review technical reports and summary documents for regulatory filings as well as

relevant sections of clinical documents, scientific presentations, and publications

Requirements:

• PhD in immunology, cell and/or cancer biology or a related field
• At least 5-7 years of relevant industrial experience with a successful relevant publication track

immunology/immuno-oncology, using multiple orthogonal techniques and human tissues
such as blood and tumor tissue samples

• Extensive hands-on experience with standard immunological techniques including multi-

parameter flow cytometry, cell sorting, immunoassays such as ELISA, immunohistochemistry,
and -omics based approaches, eg, single-cell RNAseq analysis, Nanostring, 10X Genomics,
multiplex immunostaining platforms, etc.

• Experience in leading IND-enabling studies
• Experience in leading implementation and execution of translational and biomarker studies in

into translational and biomarker research

About Immunitas

Immunitas was founded in 2019 by a team of world-class academic scientists who are harnessing
significant advancements in the field of single-cell genomics and computational biology to unlock
novel targets in human immunology. Our start-up team is collaborative and scientifically rigorous.
We’re excited to be working on cutting edge science. We are based in Waltham, MA. We offer
competitive compensation, equity, healthcare, and other benefits.

The founding scientific team is led by Kai Wucherpfennig, M.D, Ph.D. (Dana-Farber Cancer Institute
and Harvard Medical School), and includes Aviv Regev, Ph.D. (Broad Institute), Dane Wittrup, Ph.D.
(MIT) and Mario Suva, M.D., Ph.D. (Massachusetts General Hospital/Harvard Medical School).

To Apply:

Please send resume and brief introduction paragraph to info@immunitastx.com. This employer
participates in E-Verify