Job Scope:

We are looking for a Supervisor of DNA Sequencing Lab as part of US Based, highly automated gene synthesis operations. The incumbent will work with the Director, Manager, staff research associate/technicians, and laboratory assistants in a multi-disciplinary manufacturing environment; supports in daily operation, maintenance, and systematic workflow of the DNA sequencing facility. The candidate in this position is responsible for training and supervision of laboratory assistants/technicians, coordinating with the relevant stakeholders in the manufacturing operations, and also sets up efficient scheduling of sequencing workflow for a minimum turnaround time. The position is also expected to help with the data analysis/bioinformatics of full DNA/plasmid sequencing data.

Key Responsibilities:

• supervise the site sequencing personnel, equipment, materials and process to ensure stable and orderly daily production
• Through knowledge of Sanger and Next Generation Sequencing(NGS) workflow, preparing DNA sequencing samples by organizing and setting up sequencing reactions, schedule sequencing runs on DNA analyzers
• Optimize and perform cleanup of sequencing reactions, operations knowledge of automated liquid handlers
• Lead sequencing team, track performance and participate in performance rating
• Analyze sequencing results, generate test reports, and give technical guidance to guide team members
• Evaluate sequencing run results, and coordinate with data analysis group
• Improve quality standards in sequence data generation, and lead key projects to continuously optimize sequencing workflow
• Perform instrument calibrations and regular maintenance including but not limited to DNA analyzers; acts as liaison with outside vendors relevant to sequencing instruments
• Troubleshoot instrument performance issues and make recommendations and/or adjustments to improve work efficiency
• Execute SOP through training and supervision. Continuously optimize SOP to improve operational efficiency
• Train and supervise lab personnel's, troubleshoot failed or poor results
• Keep abreast with the latest advancement in sequencing technologies, develop new protocols for streamlined as well as to handle complex workflow, and provide suggestions
• Responsible for team building and day to day management, including 5S, quality data generation, safety, and employee morale
• Other tasks as assigned

Qualifications

• Bachelor's or Master's degree in Biology, Biochemistry, Molecular Biology. Chemistry or related fields
• 2 years of hands-on experience in DNA Sequencing platform(Sanger and/or NGS), analyzing DNA materials, sequencing workflow management, and data analysis
• Good understanding in the quantification and qualification methods of plasmid DNA, including spectrophotometric analysis, and electrophoresis
• Team management experience is preferred
• Must have experience working in a high throughput manufacturing environment, and flexible to modification in work environment
• Strong team management, communication and coordination skills
• Basic knowledge of molecular biology required, knowledge in project management, 5S management, quality management systems are preferred
• Experience with automation tools is preferred
• Have a strong sense of work responsibility and cost awareness

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