Biochemist

Job ID: req3329
Employee Type: exempt full-time
Division: Cancer Research Technology Program
Facility: Frederick: ATRF
Location: 8560 Progress Dr, Frederick, MD 21701 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.
Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

PROGRAM DESCRIPTION

The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. Within the CRTP, the Advanced Cryo-Electron Microscopy Technology Group explores emerging imaging platforms and develops methodologies, focusing on projects with the potential to make cryo-EM a more widely accessible technique. The team’s focuses on single-particle analysis and cryo-electron tomography. Our structure-determination methods are initially developed on standard cryo-EM specimens, such as beta-galactosidase, and later applied to more biologically relevant samples, especially where high-resolution information is needed to provide mechanistic insights. Ultimately, the goal is to sufficiently streamline the process to efficiently obtain high-resolution cryo-EM structures for a broad range of targets.

KEY ROLES/RESPONSIBILITIES

• Sample preparation and grid optimization of challenging samples for single particle and tomography cryo-EM studies
• Process cryo-EM data using various available software packages
• Keep up to date with developments in the field, proposing and implementing changes as necessary and learning and applying new techniques where appropriate

BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

• Possession of a PhD degree in biochemistry, biophysics, or related field from an accredited college or university according to the Council for Higher Education Accreditation (CHEA). Foreign degrees must be evaluated for U.S. equivalency
• Ability to obtain and maintain a security clearance

PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferential consideration:

• Experience in structural biology, with emphasis on cryo-EM
• Experience with model building programs
• Strong motivation and ability to learn and practice new concepts/tools/techniques
• Ability to work both independently and collaboratively as a team member

JOB HAZARDS

• This position is subject to working with or have potential for exposure to infectious material, requiring
  medical clearance and immunizations
• This position is subject to working with radioactive material and requires to become an approved
  radiation worker

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)
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