2 Scientist, Discovery Research Jobs in San Carlos, CA

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Scientist, Discovery Research

CARGO-Therapeutics

San Carlos, CA | Full Time

$126k-165k (estimate)

1 Month Ago

Clinical Research Scientist - Translational Scientist

Natera

San Carlos, CA | Full Time

$83k-109k (estimate)

9 Months Ago

Scientist, Discovery Research

CARGO-Therapeutics San Carlos, CA

$126k-165k (estimate)

Full Time 1 Month Ago

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CARGO-Therapeutics is Hiring a Scientist, Discovery Research Near San Carlos, CA

CARGO Therapeutics is a pioneering clinical stage biotechnology company dedicated to revolutionizing cell therapy. We are leveraging innovative technologies with a commitment to advancing therapeutic outcomes for a wider patient population while fostering a culture where individuals can thrive both personally and professionally.

CARGO is seeking a highly motivatedand innovative Scientist to join the Discovery Research team and contribute to the design, engineering and selection of best-in-class CAR T-cell therapies. First generation CAR T products have led to transformative outcomes for patients afflicted with cancer, but challenges remain due to limited accessibility and disease relapse. Reporting to a project team leader, the candidate scientist will be a key member of a growing Research team that is committed to developing broadly accessible next generation CAR T therapies that overcome mechanisms of tumor escape.

The candidate will carry out and help to lead preclinical studies to evaluate various cutting edge in-house technologies that enhance function of CAR T-cells. The scientists’ role will involve biological interrogation of T-cell edits that drive persistence, resist immune rejection, overcome loss of antigen and costimulatory signaling, and enhance overall fitness. This role will address complex immunology and will require the candidate to explore and implement multiple cell engineering solutions into a single product design. In addition, the candidate will interface with other teams in Research, Manufacturing and Clinical to advance lead candidates towards IND submission. Direct experience with the engineering of primary immune cells, immunological cell-based assays and flow cytometry are preferred experiences for this role.

The role is based in San Carlos, CA.

WHAT YOU’LL DO AT CARGO THERAPEUTICS

Design and screen complex multicistronic viral vectors harboring novel transgenes that enhance CAR T function and persistence
Assess internal and external technologies with responsibilities including initial molecular design, primary T-cell transduction and expansion, and functional characterization in advanced in vitro assays
Develop robust in vitro models that assess immune rejection of CAR T-cells
Support In Vivo team in the evaluation of candidate CAR T-cells in tumor xenograft studies
Document detailed experimental protocols and results in electronic lab notebook (ELN)
Present research findings regularly at internal and cross-functional meetings
Collaborate with team members and assist other research projects as needed
Keep abreast with relevant scientific literature and competitive landscape

THE RIGHT STUFF: Required Experience & Qualifications

Ph. D in immunology, synthetic biology or related field with 0-2 years of experience, or B.S. or M.S. with 4-6 years of relevant work experience (preferred experience with developing cell therapies)
Scientific expertise with immunology (focus on T-cell signaling and immune rejection), cell therapy, and/or cancer biology
Proficiency with handling and engineering of primary human lymphocytes and transformed cell lines, including transfection and lentiviral transduction is essential
Experience with in vitro characterization including but not limited to multicolor flow cytometry, continuous (incucyte) killing assays, cytokine assays and mixed lymphocyte reactions is preferred
Ability to design and construct complex multicistronic viral vectors is a plus
Experience with gene editing approaches (i.e. shRNA, CRISPR) is a plus
Detail-oriented in conducting and recording experiments
Effective communication skills with proven track record of publishing in scientific journals/conferences

PAY RANGE

The combined pay range for this role is $99,000 - $136,000. Title and salary will be based on our assessment of skills and experience relevant to our needs for the role.

ABOUT CARGO THERAPEUTICS

CARGO Therapeutics, Inc. is a clinical-stage biotechnology company positioned to advance next generation, potentially curative cell therapies for cancer patients. CARGO’s programs, platform technologies, and manufacturing strategy are designed to directly address the limitations of approved cell therapies, including limited durability of effect, safety concerns and unreliable supply. CARGO is currently evaluating its lead program, CRG-022, an autologous CD22 chimeric antigen receptor (CAR) T-cell therapy candidate, in a potentially pivotal Phase 2 clinical trial in patients with large B-cell lymphoma (LBCL) whose disease relapsed or was refractory (R/R) to CD19 CAR T-cell therapy. CARGO also plans to evaluate CRG-022 in patients at earlier stages of disease, including LBCL and other hematologic malignancies. Beyond its lead program, CARGO is leveraging its proprietary cell engineering platform technologies to develop a pipeline of programs that incorporate multiple transgene therapeutic “cargo” designed to enhance CAR T-cell persistence and trafficking to tumor lesions, as well as to help safeguard against tumor resistance and T-cell exhaustion. CARGO’s founders are pioneers and world-class experts in CAR T-cell therapy, and its team has significant experience and success developing, manufacturing, launching and commercializing oncology and cell therapy products. For more information, please visit the CARGO Therapeutics website at https://cargo-tx.com/.

Join us to help make a difference!

EEO & EMPLOYMENT ELIGIBILITY

CARGO Therapeutics, Inc. is committed to building a diverse, equitable, and inclusive company. We provide equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability, or veteran status. CARGO Therapeutics, Inc. also complies with all applicable national, state, and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification required of applicable law.

CARGO Therapeutics requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at CARGO Therapeutics, and it applies regardless of whether the position is located at a CARGO Therapeutics site or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.