About Capstan Therapeutics

Capstan Therapeutics, Inc. is a privately held biotechnology company dedicated to advancing in vivo cell reprogramming. The core platform technology comprises proprietary targeted lipid nanoparticles (tLNPs) that are composed of LNPs conjugated with a recombinant protein binder, such as a monoclonal antibody. tLNPs are designed to deliver payloads, including mRNA or gene editing tools, capable of reprogramming specific cell types in vivo. The platform technology has the potential to generate transformative therapies with possible applications across a broad range of disease areas, including oncology, autoimmune disorders, fibrosis, and monogenic blood disorders.

The Opportunity

Capstan is seeking a highly motivated Senior Research Associate to join the Analytical Development team. In this role, you will be responsible for analytical method development/optimization and contributing to routine testing for characterization of our LNPs/tLNPs along with its individual components. This role requires a strong attention to detail with a quantitative/analytical mindset and drive to tackle complex problems in a dynamic environment.

Responsibilities & Duties:

• Develop and optimize analytical methods to characterize LNPs/tLNPs along with their individual components.
• Maintain detailed and comprehensive documentation and electronic lab notebook (ELN) entries for all performed experiments and assays.
• Prepare and review reports/presentations to support process development, stability, and product characterization.
• Collaborate with internal and cross-functional teams to ensure accuracy and reliability of data output in addition to troubleshooting out of trend results.
• Participate in team meetings to discuss methods/data in addition to contributing insights and suggestions for any improvements to operations, analytical procedures, methods, SOPs, etc.
• Follow safety procedures/guidelines, protocols, and Standard Operating Procedures (SOPs).
• Mentor and train members of the analytical team.
• Support analytical lab operations through equipment maintenance, organizing and maintaining inventory, aliquoting and labeling, and other tasks as needed.

Requirements/Qualifications:

• Generally met with a bachelor’s degree (or equivalent) and 4 years industry experience.
• Bachelor’s degree in Analytical Chemistry, Chemistry, Biochemistry, Pharmaceutical Sciences, or other related science field is preferred.
• Proficiency in any of the following desired:
• High-Performance Liquid Chromatography (HPLC), Liquid Chromatography Mass Spectrometry (LCMS), Fragment Analyzer, Capillary Electrophoresis
• Chromeleon, Xcalibur, ProSize, 32 Karat
• Various analytical techniques such as UV-Vis spectroscopy, Dynamic Light Scattering (DLS), osmometers, plate-based assays, etc.
• Biochemical techniques including quantitative Polymerase Chain Reaction (qPCR)/Digital Droplet PCR (ddPCR), Enzyme-Linked Immunosorbent Assay (ELISA), western blotting, gel-based assays, tissue culture, etc.
• Demonstrated adaptability and comfort in dynamic work environments.
• Meticulous attention to detail alongside proven problem-solving and organizational skills.
• Excellent written and verbal communication skills.
• Flexibility to work overtime when necessary, as a prerequisite.

Salary & Benefits Offerings:

• Salary range is $90,000 - $105,000/year depending on experience.
• Performance bonus & Equity
• 401k Match Program
• Healthcare Coverage
• Dental Coverage
• Vision Coverage
• Optional Dependent Care Account
• Flexible Spending Account (FSA)
• Paid Time Off (PTO)
• Company Paid Holidays
• Paid Sick Leave
• Onsite Fully Stocked Kitchens