Research Lab Tech II, Pathology, 20 Hours

GENERAL SUMMARY:

The focus of the lab is to understand intestinal barrier loss (sometimes referred to as “leaky gut”) in Crohn’s disease, ulcerative colitis, and other immune-mediated intestinal diseases. Ongoing projects include:

• In vitro analyses of protein interactions that modify the barrier.

• In vivo determination of barrier loss and restoration effects on disease.

• Development and testing of novel therapies.

Under supervision of PI, work independently to:

• Manage experimental mouse colony.

• Provide experimental support to other lab members.

Hours are flexible, but will require 20 hours of work/week.

The lab environment includes members from diverse backgrounds who collaboratively drive discovery and teach one another.

• Training in specific skills can be provided by current lab members.

• A wide range of tools are used, including genetically-modified (knockout/transgenic) mice, patient biopsies, and cutting-edge microscopy approaches.

• Continuing education occurs informally, during lab meetings and journal clubs, and through independent reading.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

With increasing independence as skills are acquired:

• Manage breeding, maintenance, and records of mouse colony.

• Tag, genotype, and transfer mice for breeding, weaning, and experimental use.

• Interact with PI and others to plan and prepare for upcoming experiments.

• Ensure that all necessary supplies, including mice, are available.

Opportunities for greater experimental involvement are available commensurate with skills and interests.

QUALIFICATIONS:

BS in biological/physical science required.

At least one year of experience in a related research setting (for TRA II).

SKILLS/ABILITIES/COMPETENCIES REQUIRED:

• Attention to detail and accuracy.

• Ability to follow existing protocols and both learn and develop new methods

• Willingness to or experience in handling laboratory mice.

• Computer literacy, including constructing a logical search of electronic records.

• Ability to identify potential problems and develop solutions.

• Capable of logically and effectively structuring tasks, setting priorities, and developing/executing long-term plans.