As our company is growing, we are seeking a Temporary Research Associate to join our expanding Drug Discovery team at our Headquarters in San Diego, CA.

WHY WORK FOR ARCTURUS?

Founded in 2013 and based in San Diego, California, Arcturus Therapeutics Holdings Inc. (Nasdaq: ARCT) is a clinical-stage mRNA medicines and vaccines company with enabling technologies: (i) LUNAR® lipid-mediated delivery, (ii) STARR™ mRNA Technology and (iii) mRNA drug substance along with drug product manufacturing expertise. Arcturus’ diverse pipeline of RNA therapeutic and vaccine candidates includes self-replicating mRNA vaccine programs for SARS-CoV-2 (COVID-19) and Influenza, and other programs to potentially treat Ornithine Transcarbamylase (OTC) Deficiency, Cystic Fibrosis, Cardiovascular Disease along with partnered programs including Glycogen Storage Disease Type 3, Hepatitis B Virus, and non-alcoholic steatohepatitis (NASH). Arcturus’ versatile RNA therapeutics platforms can be applied toward multiple types of nucleic acid medicines including messenger RNA, small interfering RNA, replicon RNA, antisense RNA, microRNA, DNA, and gene editing therapeutics. 

Arcturus’ technologies are covered by its extensive patent portfolio (192 patents and patent applications, issued in the U.S., Europe, Japan, China and other countries). Arcturus’ commitment to the development of novel RNA therapeutics has led to collaborations with Janssen Pharmaceuticals, Inc., part of the Janssen Pharmaceutical Companies of Johnson & Johnson, Ultragenyx Pharmaceutical, Inc., Takeda Pharmaceutical Company Limited, CureVac AG, Synthetic Genomics Inc., Duke-NUS, and the Cystic Fibrosis Foundation. 

Arcturus Therapeutics is presently recruiting outstanding candidates with experience in the field of mRNA technologies and nanoparticle sciences. 

Our corporate culture is dynamic, diverse, and creative. We value collaboration and teamwork. We seek individuals to join us with a genuine passion for the science behind helping to cure disease and improve the lives of patients.

THE OPPORTUNITY

In this role, you will support scale-up, manufacturing, and characterization of lipid nanoparticle-based nucleic acid formulations to support our emerging research pipeline. Our ideal candidate will bring a willingness to learn and contribute to our formulation production and purification processes.

WHAT YOU WILL CONTRIBUTE 

• Develop and nucleic based formulations including complex nanoparticle formulations;
• Prepare and characterize dose formulations for various in vitro and in vivo studies;
• Perform process-related investigations, identify root causes of process/manufacturing discrepancies, evaluate systems for trends and adverse findings, and implement appropriate steps to ensure process robustness;
• Perform formulation stability studies, contact material compatibility, and stability the study, in-use compatibility study, and accelerated stability studies;
• Maintain proper documentation of all experimental procedures and results, including batch records, protocols, Standard Operating Procedures (SOPs) and other manufacturing related documentation;
• Prepare technical reports and presentations which summarize procedures, study results, and data interpretation as needed;
• Deliver high quality results in an accurate and a time sensitive manner
• Maintain accurate and timely records
• Perform other activities as needed

WHAT WE SEEK

• Related experience in a life science, pharmaceutical company or academic lab setting;
• Experience with nucleic acid based formulations, complex/nanoparticle formulations, nucleic acid based formulation and working knowledge of tangential flow filtration;
• Hands on expertise working with liquid, frozen, and/or lyophilized dosage forms;
• Familiarity with stages of drug product development and cGMP concept, knowledge of analytical methods for testing lipid nanoparticles and understanding of the in-vitro and in-vivo experiments used for screening of nanoparticle formulation highly preferred;
• Comfortable working in a highly innovative, changing, fast-paced environment required;
• Ability to work overtime, as required, including weekends;
• Willingness and motivation to learn new techniques and protocols

EDUCATION 

WHAT WE OFFER

An exciting opportunity to join a company that offers a competitive total rewards package that includes:

• Free variety of snacks and beverages
• Health and Wellness programs
• On Campus Gym 
• Company sponsored FUN events

For a deeper dive into our company and corporate culture visit www.ArcturusRx.com