Senior Scientist, DMPK

Who we are:

Agios is a biopharmaceutical company that is fueled by connections. We thrive in a supportive, fun, and flexible environment full of people empowered to bring their whole selves to work. We care deeply about our work, each other, and the patients who count on us. Our teams cultivate strong bonds with patient communities, healthcare professionals, partners and colleagues, which helps us discover, develop and deliver therapies for rare diseases – and make a bigger difference in their lives. In the U.S., Agios markets a first-in-class pyruvate kinase (PK) activator for the treatment of hemolytic anemia in adults with PK deficiency. Building on the company’s leadership in the field of cellular metabolism, Agios is advancing a robust clinical pipeline of investigational medicines with active and planned programs in alpha- and beta-thalassemia, sickle cell disease, pediatric PK deficiency and MDS-associated anemia.

The impact you will make:

Agios Pharmaceuticals is searching for a dynamic Senior Scientist, DMPK to join our growing DMPK team. We want someone who cares about this important work, and who’s driven to connect to our mission of helping these patient communities. The Senior Scientist will be responsible for targeted quantitative analysis of drugs and biomarkers using LC-MS/MS. Responsibilities will grow to also include metabolomics and pathway analysis. The position will support PK/PD studies from multiple projects in the discovery and translational space and work closely with Biology and Pharmacology to help identify novel biomarkers for preclinical or clinical-stage assets. The Senior Scientist will spend up to 50% of time with hands-on bioanalysis in the Agios laboratories and be responsible for managing multiple LC/MS systems and overseeing work performed at contract research organizations.

What you will do:

• Support PK/PD studies from multiple projects in the discovery and translational space and work closely with Biology and Pharmacology to help identify novel biomarkers for preclinical or clinical-stage assets. 
• Develop and optimize LC and ion-pairing LC-MS/MS methods for the analysis of endogenous metabolites in complex biological samples such as blood and organ homogenate with high level of autonomy.
• Perform quantitative analysis of various drug modalities and biomarkers using LC-MS/MS via calibration curves, internal standards, endogenous QCs, and surrogate analytes/matrices.
• Maintain and troubleshoot Sciex triple quadrupole and/or Thermo Orbitrap high-resolution LC-MS/MS systems to ensure consistent analytical support for projects.
• As needed, oversee all aspects of bioanalysis at Contract Research Organizations, including project management (budget, timing, logistics, execution, reporting), method development, quantitative bioanalysis, metabolomics, and proteomics

What you bring:

• MS or PhD with at least 5 years industry experience providing bioanalytical support to drug discovery project teams.
• Experience in sample preparation techniques for routine pharmacokinetics and/or metabolomics analysis, including extraction and derivatization, where needed.
• Familiarity in performing quantitative analysis of various drug modalities and biomarkers using LC-MS/MS.
• Ability to expand skills into untargeted metabolomics, including endogenous metabolite identification, bioinformatics tools, and statistical calculations for interpretation of LC-MS/MS data and development of sound biochemical hypotheses. 
• Experience with triple quadrupole and high-resolution LC-MS/MS systems.
• Familiarity with isotope tracer techniques and corresponding analyses is a plus.
• Effective communication of research findings through presentations and publications.

Work Location:

Location Specific – Onsite: This role requires the majority of work to be completed onsite at our Cambridge Headquarters. While it is expected that this role will be onsite a minimum of 4 days a week, Agios values flexibility, and flexible schedules around onsite work are available. Regular conversations with manager are encouraged to ensure alignment on in-person presence/expectations. Employees in this role are expected to live within a commutable distance to the office.

What we will give you:

• Deliberate Development. Your professional growth as one of our top priorities. 
• Flexibility. We are all about individual needs. We embrace different perspectives, work styles, health and wellness approaches, care of families and productivity. When you are at your best, we are at our best. 
• Premium benefits package. We invest in the health, wellbeing, and security of our people with a premium benefits package that is well-rounded and flexible to help meet the varied personal and professional needs of every member of our team.
• Competitive performance-based compensation. This includes both short- and long-term incentives that are connected to our business strategy.
• Psychological safety. We support an environment of fearlessness. We want you to share your ideas, speak candidly and take data-informed risks to help push the boundaries.
• Commitment to diversity. We strive to foster a welcoming workplace where everyone can thrive. We are continuously looking to improve the inclusivity of our workforce.
• Commitment to community. We are an active participant in the communities that surround us – the communities where we live, and the community of people and their loved ones in need of better treatment options for conditions that are often overlooked.

Interested in learning more about what makes our culture unique? Visit the Inside Agios section of our website.