Scientist II

The Fountain Group is currently seeking a Scientist II - Biologics CMC Developability for a prominent client of ours. This position is located at Worcester, MA. Details for the position are as follows:

Scientist II - Biologics CMC Developability

Location: Worcester, MA (Onsite)

Pay Rate: $48-$52/hr

Duration: 12 Months (High Possibility of Extension)

Job Description

Seeking a Scientist II to join the Biologics CMC Developability team supporting discovery-stage biologic drug candidates. This role focuses on LC-MS and chromatography-based characterization of therapeutic proteins to evaluate developability, identify critical quality attributes, and support biologics drug development.

• Perform LC-MS characterization of therapeutic biologics and post-translational modifications (PTMs)
• Conduct protein characterization using size exclusion (SEC), ion exchange (IEX), and reverse-phase liquid chromatography
• Perform protein mass spectrometry including subunit analysis, peptide mapping, and disulfide mapping
• Execute experimental protocols, analyze data, and interpret characterization results
• Maintain accurate documentation using electronic laboratory notebooks (ELN)
• Prepare and present scientific summaries of experimental findings
• Support maintenance and qualification of analytical laboratory equipment
• Contribute to characterization of critical CMC attributes for biologic drug candidates
• Collaborate with cross-functional teams supporting biologics development
• Ensure compliance with laboratory safety, documentation, and quality standards
  
  

Education

• BS or MS in Biochemistry, Biology, Chemistry, Chemical Engineering, Pharmaceutical Sciences, or a related discipline with relevant biopharmaceutical industry experience; OR
• PhD in a related field with applicable industry or research experience
  
  

Required Skills

• Biologics characterization
• Liquid chromatography-mass spectrometry (LC-MS)
• Protein mass spectrometry
• Peptide mapping
• Subunit analysis
• Disulfide mapping
• Post-translational modification (PTM) analysis
• Size Exclusion Chromatography (SEC)
• Ion Exchange Chromatography (IEX)
• Reverse-Phase Liquid Chromatography (RP-LC)
• Therapeutic protein characterization
• Biologics CMC developability
• Electronic Laboratory Notebook (ELN)
• GraphPad Prism
• Microsoft Excel
• Experimental design and data analysis
  
  

Preferred Skills

• Liquid handling robotics
• Laboratory automation programming
• Discovery-stage biologics development
• Biopharmaceutical CMC development
• Protein developability assessment
• Analytical method optimization
• Cross-functional biologics research
  
  

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