Clinical Site Operations Lead

Piper Companies is seeking an experienced Clinical Site Operations Lead to oversee and elevate the performance of clinical research site activities in a dynamic and fast-moving environment. This role is essential in guiding site personnel, ensuring operational excellence across studies, and improving overall site delivery through strong leadership and process optimization. This is a full-time onsite opportunity working closely with cross-functional clinical teams in a collaborative setting located in Downers Grove, IL.

Responsibilities for the Clinical Site Operations Lead include:

• Leading and directing daily activities of site-based staff such as Clinical Research Coordinators and Nurses, ensuring appropriate workload distribution and prioritization.
• Driving the successful execution of study start-up, ongoing site management, and closeout activities in alignment with internal procedures and protocol requirements.
• Tracking and evaluating operational performance metrics, and implementing improvements to enhance efficiency and site experience.
• Partnering with cross-functional stakeholders including project managers and monitoring teams to address and resolve site-level challenges.
• Supporting the growth and performance of team members through coaching, training, and regular feedback.
• Contributing to the refinement of operational processes, systems, and documentation to support continuous improvement initiatives.
  
  

Qualifications for the Clinical Site Operations Lead include:

• Bachelor’s degree in a life sciences discipline, healthcare, business, or a related field.
• Background in oncology-focused clinical research.
• Hands-on experience in clinical site operations, trial support, or broader clinical operations functions.
• Prior experience in a leadership, supervisory, or mentorship capacity is strongly preferred.
• Solid knowledge of clinical trial execution, including regulatory standards such as Good Clinical Practice (GCP) and essential documentation requirements.
• Strong interpersonal, communication, and organizational capabilities.
• Demonstrated ability to manage multiple studies and shifting priorities in a fast-paced environment.
• A proactive, team-oriented approach with a strong emphasis on quality and stakeholder satisfaction.
  
  

Compensation for the Clinical Site Operations Lead includes:

• Salary range: $80,000 - $90,000
• Comprehensive benefits package including Medical, Dental, Vision, 401k, PTO, holidays, and sick leave as required by law.
  
  

Keywords: Clinical Site Operations, Clinical Research Leadership, site management, Clinical trial operations, site oversight, research site coordination, study start-up, site maintenance, close-out activities, SOP compliance, clinical trial execution, operational metrics, process improvement, workflow optimization, team supervision, staff development, performance management, mentorship, oncology, clinical research, good clinical practice, GCP, regulatory compliance, site documentation, clinical study protocols, leadership, clinical trial systems

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This job is open for applications on 6/4/2026 and will remain open for at least 30 days from the posting date.