What are the responsibilities and job description for the Postdoctoral Fellow position at National Institutes of Health?
A postdoctoral position is available in the Kinase Complexes Section (KCS), Center for Structural Biology (CSB), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Frederick, MD.
About the position
The candidate will perform basic research in molecular biology/structural biology/biochemistry. The KCS group studies the structural and molecular mechanisms of kinase signaling complexes that are linked to human cancers and other diseases, with a long-term goal of developing new therapeutic strategies. Our current research objectives focus on an oncogenic protein kinase PKA fusion J-PKAcα, the RAF family kinases, and the leucine rich repeat kinases (LRRKs). We use interdisciplinary biochemical and structural approaches, including X-ray crystallography and cryo-electron microscopy, to decipher the structure and function of these challenging kinase complex systems.
The research of the group is supported by the collaborative and interdisciplinary NIH intramural program, which includes more than 1100 labs and provides state-of-the-art equipment in structural biology, biochemistry, and biophysics. These core facilities are supported by Ph.D. level staff and offer hands-on training.
In addition, NIH is committed to the continuing education and career development of its research staff through numerous courses and workshops offered by NIH Office of Intramural Training & Education and Foundation for Advanced Education in the Sciences. There are also opportunities for intramural career transition funding (K grants).
We have excellent access to high-end microscopes (Titan Krios/Cold FEG/Selectris / Falcon IV, Arctica/BioQuantum/K3 and Aquilos II CryoFIB available locally in addition to smaller testing microscopes); crystallography (experience in protein crystal structure determination). We have excellent access to Synchrotron beamlines and in-house X-ray diffraction and SAXS cores.
The candidate must be highly motivated to participate in rigorous and innovative research programs and possess excellent work ethic and team spirit, be able to work independently and efficiently and collaborate closely with members of the group, and other labs on joint projects.
What you'll need to apply
Interested candidates must have a Ph.D. or M.D. degree with less than 5 years of postdoctoral experience. U.S. citizenship or permanent residency is required.
Applicants must have a strong background in molecular biology, structural biology, biochemistry, cell biology or a related discipline. The candidate should have good oral and written skills in English. The candidate should be skilled in at least one of the following areas:
- biochemistry and molecular biology (experience in protein purification from different expression systems of soluble and membrane proteins)
- electron microscopy (experience in cryo-EM sample preparation and digital image processing)
- cell biology
If interested, please submit:
- CV/Resume
- 3 References
- Cover Letter
- Summary of Research Experience
Contact name
Ping Zhang
Contact email
ping.zhang@nih.gov
Disclaimer/Fine Print
U.S. citizens and permanent residents are eligible to apply.