What are the responsibilities and job description for the Postdoctoral Fellow position at Marshall University?
Job Summary:
The Xu Lab in the Department of Biomedical Sciences is seeking a motivated and skilled Postdoctoral Fellow to join our team. The candidate will lead a research project focusing on molecular microbiology of infectious diseases. One focus of this role involves inhibitor design and validating these targets. The ideal candidate will possess extensive hands-on experience in microbial construct design, genetic transformation, recombinant protein expression, and targeting those proteins with biochemical inhibitors.
The Xu Lab in the Department of Biomedical Sciences is seeking a motivated and skilled Postdoctoral Fellow to join our team. The candidate will lead a research project focusing on molecular microbiology of infectious diseases. One focus of this role involves inhibitor design and validating these targets. The ideal candidate will possess extensive hands-on experience in microbial construct design, genetic transformation, recombinant protein expression, and targeting those proteins with biochemical inhibitors.
Key Responsibilities:
Inhibitor Design: Apply computational tools (docking, molecular dynamics) or experimental methods to design and screen small-molecule, peptide, or fragment-based inhibitors against target proteins.
Inhibitor Design: Apply computational tools (docking, molecular dynamics) or experimental methods to design and screen small-molecule, peptide, or fragment-based inhibitors against target proteins.
- Assay Development: Establish biochemical, biophysical, and cellular assays to measure inhibitor binding affinity and functional enzyme inhibition.
- Construct Cloning: Design and construct expression plasmids, genetic vectors, and CRISPR-based tools for bacterial/host systems.
- Strain Engineering: Engineer microbial strains and mammalian cells.
- Protein Expression: Purify target proteins using chromatographic methods.
- Characterization: Perform biochemical characterization, Western blotting, ELISA, and functional assays to validate protein activity.
Required Qualifications
Education
- Ph.D. in Microbiology, Molecular Biology, Biochemistry, Medicinal Chemistry, or a closely related field.
Experience
- Demonstrated experience in inhibitor design, structural biology, or biochemical assay development for target evaluation.
- Proven expertise in molecular cloning techniques (Gibson assembly, restriction-based, PCR).
- Hands-on experience with bacterial transformation and genetic manipulation.
- Strong background in recombinant protein expression and purification.
- Evidence of productivity: At least one first-author publication in a peer-reviewed journal.
- Experience using structural biology or computational chemistry software (e.g., PyMOL, Schrödinger, AutoDock, Rosetta).
- Experience with biophysical characterization techniques (e.g., SPR, ITC, MST).
- Knowledge of bioinformatics tools for gene/protein analysis.
Preferred Qualifications
Education
Experience
Posting Detail Information
Posting Number MR0884 Open Date 07/23/2026 Close Date Open Until Filled Yes Special Instructions Summary
Please include the following with your application:
- A cover letter detailing research experience and interest in the position.
- Curriculum Vitae (CV) with a publication list.
Benefits:
Sick Leave, Paid HolidaysSalary : $42,972 - $65,806