What are the responsibilities and job description for the Postdoctoral Fellow position at marshall?
Job Summary:The Xu Lab in the Department of Biomedical Sciences is seeking a motivated and skilled Postdoctoral Fellow to join our team. The candidate will lead a research project focusing on molecular microbiology of infectious diseases. One focus of this role involves inhibitor design and validating these targets. The ideal candidate will possess extensive hands-on experience in microbial construct design, genetic transformation, recombinant protein expression, and targeting those proteins with biochemical inhibitors.Key Responsibilities:Inhibitor Design: Apply computational tools (docking, molecular dynamics) or experimental methods to design and screen small-molecule, peptide, or fragment-based inhibitors against target proteins.Assay Development: Establish biochemical, biophysical, and cellular assays to measure inhibitor binding affinity and functional enzyme inhibition.Construct Cloning: Design and construct expression plasmids, genetic vectors, and CRISPR-based tools for bacterial/host systems.Strain Engineering: Engineer microbial strains and mammalian cells.Protein Expression: Purify target proteins using chromatographic methods.Characterization: Perform biochemical characterization, Western blotting, ELISA, and functional assays to validate protein activity.