Principal Research Scientist

Job Title: DMPK Project Representative (Sr. Scientist)

Location: Lexington, MA (Onsite)

Type: 1-year contract (possible extension or conversion to permanent)

Schedule: Full-time, onsite

Start: ASAP

Pay Rate: $120/hour on W2 - $135/hour on W2

🔍 About the Role

We are seeking a highly skilled Sr. Scientist to serve as a DMPK Project Representative supporting small-molecule drug discovery programs across multiple therapeutic areas. This position plays a key role in integrating DMPK strategy into discovery efforts and collaborating with cross-functional teams to advance high-quality drug candidates.

The ideal candidate is a recognized ADME or PK/PD subject matter expert with a strong publication record and significant experience in project-facing scientific leadership.

✨ Top Skills & Experience Needed

• 3 years in a project-facing scientific role
• Expertise in ADME or PK/PD modeling
• Relevant publications/abstracts in metabolism, DDI, or PK/PD modeling
• Ability to design, interpret, and communicate complex DMPK data
• Strong collaboration experience with CROs and cross-functional teams

🧪 Key Responsibilities

• Serve as the DMPK project representative on global, cross-functional small molecule project teams
• Provide expert guidance on experimental plans and data interpretation (ADME, PK/PD, DDI)
• Lead and troubleshoot complex in vitro, in vivo, and in silico DMPK studies
• Collaborate with medicinal chemistry, pharmacology, outsourcing teams, and external partners
• Lead the design, execution, and interpretation of DMPK experiments conducted internally or by CROs
• Integrate disparate datasets and deliver clear, actionable conclusions to stakeholders
• Maintain thorough documentation of all studies and results
• Contribute to publications, project reports, milestone documents, and scientific presentations
• Represent the organization externally at conferences and scientific meetings
• Mentor or guide junior staff members as needed

📘 Qualifications

• Bachelor’s degree with 18 years of relevant experience
• OR Master’s degree with 12 years of relevant experience
• OR Doctoral degree with 6 years postdoctoral and/or industry experience
• Strong understanding of ADME principles; PK/PD modeling or biotransformation preferred
• Experience with outsourced ADME models (fully or hybrid) is a plus
• Excellent verbal and written communication skills
• Demonstrated ability to collaborate effectively in global, cross-functional environments