What are the responsibilities and job description for the Principal Research Scientist position at Contemporary Staffing Solutions?
Principal Scientist, Bioanalytical Method Development (LC-MS/MS)
Location: Lenexa, KS
Employment Type: Full-Time
We are seeking an experienced Principal Scientist to lead bioanalytical method development efforts supporting preclinical and clinical research programs. This is a high-impact scientific leadership role responsible for driving assay strategy, overseeing complex LC-MS/MS method development and validation activities, and serving as a key scientific partner to clients and internal stakeholders.
This opportunity is ideal for a scientist with deep expertise in bioanalytical method development, emerging biologic modalities, and the ability to lead complex projects from concept through execution.
Key Responsibilities
- Independently lead the development, optimization, and validation of LC-MS/MS bioanalytical assays.
- Design and implement robust methods supporting small molecules, radiolabeled analytes, and biologics.
- Oversee assay development utilizing automated technologies and laboratory platforms including Tomtec, Hamilton, KingFisher, Integra Assist Plus, and related systems.
- Support successful transfer and implementation of validated methods across laboratory locations.
- Review scientific data packages, presentations, and reports to ensure technical accuracy and quality.
- Provide scientific guidance and troubleshooting support to laboratory operations teams.
- Collaborate cross-functionally on validation plans, study reports, SOPs, and regulatory documentation.
- Serve as a scientific consultant to clients, advising on assay strategies and study requirements.
- Contribute to scientific publications, conference presentations, and technical thought leadership activities.
- Support business development initiatives by providing scientific expertise during client engagements and proposal development.
Qualifications
Required
- PhD in Biology, Chemistry, Pharmacology, Biochemistry, Pharmaceutical Sciences, or a related scientific discipline.
- Master's degree candidates will be considered with significant, relevant LC-MS/MS bioanalytical method development experience.
- Demonstrated expertise in bioanalytical assay development and validation within pharmaceutical, biotechnology, CRO, or clinical research environments.
- Strong experience with LC-MS/MS methodologies supporting preclinical and clinical studies.
- Experience working with biologics and complex modalities including:
- Proteins
- Peptides
- Antibody-drug conjugates (ADCs)
- Oligonucleotides
- Monoclonal antibodies (mAbs)
- Radiolabeled compounds
- Proven track record of leading scientific projects and interacting with external clients or study sponsors.
- Strong analytical, problem-solving, and data interpretation skills.
- Excellent written and verbal communication skills with the ability to present complex scientific concepts to diverse audiences.
Preferred Experience
- Method transfer and validation across multiple laboratory sites.
- Scientific authorship, conference presentations, or industry publications.
- Client-facing scientific consulting and business development support.
- Experience supporting regulated bioanalytical studies in a GxP environment.
Why Consider This Opportunity?
- Lead cutting-edge bioanalytical programs supporting breakthrough therapies.
- Work with emerging drug modalities across a diverse client portfolio.
- Influence scientific strategy and assay innovation at a global level.
- Collaborate with multidisciplinary teams of scientists and industry experts.
- Opportunity to publish, present, and establish thought leadership within the scientific community.