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Senior Principal Scientist (Sr. Research Scientist), Bioanalytical

ICON plc
Lenexa, KS Full Time
POSTED ON 9/17/2026
AVAILABLE BEFORE 11/2/2026
Senior Research Scientist- Onsite, Lenexa, KS- Full-Time; Flow Cytometry

ICON plc is a world-leading healthcare intelligence and clinical research organization. We’re proud to foster an inclusive environment driving innovation and excellence, and we welcome you to join us on our mission to shape the future of clinical development.

We are excited to be seeking a new Senior Principal Scientist (Sr. Research Scientist) at ICON in Lenexa, Kansas (KS). The Senior Principal Scientist (Sr. Research Scientist) will lead and conduct scientific research aimed at advancing clinical trials and developing innovative therapies. You will manage sponsor programs, shape assay strategies, and provide expertise for new and complex modalities.

We are seeking candidates with proven method development and Spectral Flow Cytometry experience.

What You Will Do

The Senior Principal Scientist is responsible for method development and validation for testing preclinical and clinical specimens using flow cytometry, and ligand-binding analytical methods. In addition, you will oversee transfer robust flow cytometry methods for further for bioanalytical testing.

Desired Experience (flow cytometry experience required, ligand binding experience preferred):

  • Flow cytometry
    • Experience with Spectral Flow
    • Panel design
    • Gating strategy design
    • Usage of cytometry software (e.g. FACSDiva, FCS express)

  • Ligand binding assays
    • ELISA, ECLIA
    • PK, PD, and immunogenicity
    • Usage of relevant software (e.g. SoftMax Pro, Watson)
Method Development

  • Designs and executes experiments for method development
  • Develops new scientific approaches to method development and communicates these to the global science team
  • Mentors junior scientists and advises operation on developed methods
  • Reviews and approves data of other scientists
  • Communicates with team members and management regarding project status, purpose, scheduling, problems, etc.
  • Lead communication with clients regarding project status.

Scientific

  • Maintain knowledge and skill in all techniques where you perform your work.
  • Provide scientific input to management and BD about new technology investments and lines of service.
  • Own discussions regarding scientific results with sponsors, together with project manager
  • Promotes ICON utilizing scientific skills through scientific communication such as external publication of posters and journal articles.
  • Perform R&D projects
  • Training of technicians on technical aspects
  • Mentor and train staff on scientific topics

Quality and Timely Work Execution

  • Takes initiative in process development and SOP/WI writing
  • Legible, logical and reproducible documentation of all experimentation
  • Has a thorough understanding and complies with GLP and other appropriate regulations
  • Develops rugged and economical assays
  • Performs data review of other scientist’s work

Sample Analysis and Assay Validation

  • Provides key assay input to the validation and bioanalysis team(s) to ensure successful execution
  • Assay troubleshooting
  • May perform and document maintenance, trouble-shooting and repairs on advanced instrumentation with support of service engineers or other trained supervisory personnel.

Qualifications

  • Read, write and speak fluent English
  • Spectral flow cytometry experience
  • 10-15 years of relevant laboratory experience
  • MS or PhD with applicable research in a relevant scientific field, preferred
  • Presenter/Publisher in Regulated relevant field, preferred

What ICON Can Offer You

Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our Benefits Examples Include

  • Various annual leave entitlements
  • A range of health insurance offerings to suit you and your family’s needs.
  • Competitive retirement planning offerings to maximize savings and plan with confidence for the years ahead.
  • Global Employee Assistance Programme, LifeWorks, offering 24-hour access to a global network of over 80,000 independent specialized professionals who are there to support you and your family’s well-being.
  • Life assurance
  • Flexible country-specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidized travel passes, health assessments, among others.

Visit our careers site to read more about the benefits ICON offers.

At ICON, inclusion & belonging are fundamental to our culture and values. We’re dedicated to providing an inclusive and accessible environment for all candidates. ICON is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know or submit a request here

Interested in the role, but unsure if you meet all of the requirements? We would encourage you to apply regardless – there’s every chance you’re exactly what we’re looking for here at ICON whether it is for this or other roles.

Are you a current ICON Employee? Please click here to apply

Salary.com Estimation for Senior Principal Scientist (Sr. Research Scientist), Bioanalytical in Lenexa, KS
$100,755 to $129,544
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