Principal Scientist – Biotherapeutics Engineering

Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using its proprietary platform to advance a pipeline of novel, tumor-activated clinical and preclinical I-O molecules that are designed to optimize their therapeutic index by localizing anti-tumor activity within the tumor microenvironment, including tumor-activated cytokines and antibodies (including bispecifics) and immune cell engagers (including tumor-activated cell engagers and tumor-activated effector-enhanced cell engagers). Learn more by visiting www.xiliotx.com and follow us on LinkedIn (Xilio Therapeutics, Inc.)

SUMMARY:

We are seeking a highly skilled and experienced Principal Scientist in Biotherapeutics Engineering to design and optimize biologics-based drugs, incorporating structural biology expertise as well as innovative computational methods. The successful candidate will have a strong background in structural biology, protein engineering and antibody discovery workflows. A solid background in applying machine learning techniques and molecular modeling to improve the biophysical and biological properties of biotherapeutics is highly desired. The candidate is expected to have expertise in leading cross-functional teams, generating key data, and driving projects from in silico concepts to in vivo proof of concept (PoC).

Job Responsibilities:

• Apply state-of-the-art in silico biotherapeutic engineering tools, CCG-MOE or Schrodinger-Maestro and/or others, to design and optimize biologics-based drugs.
• Apply cutting-edge generative AI, machine learning and molecular modeling techniques to help identify novel binders and/or enhance the properties of biologics-based drugs, including target engagement, developability, immunogenicity, and protease specificity.
• Perform biochemical and biophysical characterization of designed/engineered proteins to examine protein function as well as identify and develop structure-function relationships.
• Lead or co-lead research project team, accountable for defining project strategy, ensuring effective execution of activities to meet project goals and timelines.
• Represent Protein Engineering at project team meetings.
• Support writing and reporting of key experiments in IND filings.
• Capture detailed experimental information in electronic lab notebook (ELN) entries.

Skills, Qualifications, and Requirements:

• PhD in Structural Biology, Chemical and Biomolecular Engineering or a related field and a minimum of 7 years of relevant post-graduate experience in industry or academic setting.
• Strong expertise in biotherapeutics engineering, with a focus on computational methods for drug design and optimization is required.
• Expertise in protein design and bioinformatics, including molecular modeling (homology modeling and molecular dynamics simulations) using in silico tools such as MOE, Maestro, NAMD, Schroedinger or VMD, etc. is required.
• Strong analytical and problem-solving skills for computational analysis of protein, DNA, and mRNA sequences is required.
• Demonstrated experience in applying machine learning techniques to improve the properties of biologics-based drugs is desired.
• Knowledge of various generative AI/machine learning algorithms (RFDiffusion, Alphafold, Chroma, etc.) and experience in data mining using APIs is desired.
• Experience in cloud computing and/or in writing code (SQL, R, python) for data wrangling and analytics is desired
• Familiarity with electronic lab notebooks (such as Benchling) for data mining and analysis is desired.
• Proven track record of leading cross-functional teams and successfully delivering projects from in silico concepts to in vivo proof of concept is preferred.
• Excellent leadership and communication skills to effectively lead cross-functional teams and collaborate with stakeholders is required.

Diversity, Equity and Inclusion

At Xilio Therapeutics, we foster a culture of equity, diversity and inclusion. We consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law. We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability who requires accommodation with the hiring process or to perform any essential functions of the position for which you are applying, please reach out to careers@xiliotx.com.

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