Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline includes clinical programs in Duchenne muscular dystrophy, Alpha-1 antitrypsin deficiency and Huntington’s disease, as well as a preclinical program in obesity. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Description

Wave seeks a highly motivated scientist to join its analytical group in Lexington, MA. This is an ideal position for an individual who is interested in learning cutting edge technologies including first-in-class RNA editing therapeutic platform under collaboration with GSK and who thrives in a team-oriented, fast-paced, and cross-disciplinary biotech environment. The senior scientist I will be responsible for leading, designing, executing, and analyzing experiments as a member of a team focused on providing analytical support to advance therapeutic programs. This candidate will contribute to analytical method development, method transfer, verification, validation, lifecycle management of analytical test methods to support on-site GMP manufacturing, stability testing and clinical programs.

Experience

• Ph.D. in chemistry, biochemistry, or related discipline with 3-8 years of industry experience; BS/MS in chemistry, biochemistry or related discipline with 5-10 years of industry experience
• Experienced in developing analytical methods using chromatography (reversed phase, normal phase, ion exchange, etc.), LCMS, NMR and related analytical techniques
• Full computer literacy and knowledge of basic scientific principles and practices
• Familiarity with GxP analytical development environment
• Prior experience in oligonucleotide method development/qualification is highly preferred, but not required

Responsibilities

• Lead or support development, troubleshooting, improvement, and life-cycle management of analytical methods
• Execute and support method qualification and validation
• Write, review and approve GMP documentation (SOPs, protocols, technical reports, specifications, etc.)
• Identify, evaluate, and procure analytical equipment and reagents
• Analyze research and production samples to support method or process development
• Summarize/present analytical findings at team or cross functional department meetings and use scientific literature to solve advanced technical problems
• Review data generated by other analysts
• Work collaboratively within multi-disciplinary team of scientists
• Independently applies scientific knowledge (both theoretical and practical) for the resolution of analytical chemistry problems
• May involve mentoring and training colleagues in quality control or other departments
• Participate in project management activities including: creating and meeting objectives for timelines, budgets, and project goals
• Demonstrated ability to learn new analytical techniques and solve complex problems
• Troubleshoot technical issues and perform investigations
• Accurately and thoroughly document procedures and results using laboratory notebooks, protocols and reports and databases
• Follow all applicable company SOPs, work instructions and guidelines
• Performs routine testing when required

Key Skills

• Instrument skills including FTIR, UV-Vis, HPLC/UPLC, LC/MS, NMR, GC, etc.
• Familiar with common chromatography/Spectroscopy acquisition/processing software
• Effective communication; proficiency in good documentation practices, data analysis and reporting
• Demonstrated ability to efficiently multitask, prioritize critical tasks
• Flexibility in adapting to different projects
• Strong team player, working with cross-functional teams in a fast paced setting
• Ability to make scientifically sound decisions

Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of Wave Life Sciences’ employees to perform their job duties may result in discipline up to and including discharge.

We value our relationships with professional recruitment firms. To protect the interests of all parties, and given the large volume of inquiries received from third-party placement agencies, we are not able to respond to all agency inquiries. We do not accept unsolicited resumes from any source other than directly from candidates for current or future positions. Submission of unsolicited resumes in advance of a signed agreement between our company and a placement agency does not create an implied obligation and, if an unsolicited candidate represented by a placement agency is hired, we are not obligated to pay a fee. Only approved recruitment firms will be allowed to provide services to Wave Life Sciences, USA.