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Principal Scientist, Translational Biology
$126k-163k (estimate)
Full Time | Pharmaceutical 3 Weeks Ago
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Verve Therapeutics is Hiring a Principal Scientist, Translational Biology Near Boston, MA

The Company

Verve Therapeutics is a biotechnology company created with a singular focus: to protect the world from heart disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, the company aims to develop transformative, once-and-done therapies for coronary heart disease. Verve's gene editing medicines are designed to safely edit the genome of adults and mimic naturally occurring gene variants to permanently lower LDL cholesterol and triglyceride levels. The company is advancing a pipeline of precision genetic medicines, led by VERVE-101, which is being developed initially for heterozygous familial hypercholesterolemia, a potentially fatal genetic heart disease. In 2023, Verve was named a Top Place to Work by The Boston Globe for the third consecutive year. Verve is headquartered in Boston, Massachusetts.

The Position

Verve is looking for a Principal Scientist, Translational Biology to lead translational biology research. This individual would be responsible for designing translational and investigative research studies to bridge the gap between early research and clinical studies, thereby supporting the strategic development of gene editing based drug products. This individual will work cross functionally within the nonclinical development team and with the clinical and regulatory teams to provide mechanistic insights and translational capabilities relevant to the development of Verve's gene editing medicines.

Job Responsibilities

  • Design and coordinate studies to understand the potential effects of gene editing products
  • Interpret and report data from investigative and translational studies to drive mechanistic understanding
  • In partnership with R&D teams, facilitate appropriate incorporation of translational medicine strategies for early and late phases of development
  • Implement and coordinate innovative biomarkers for defined endpoints based on the best available science and emerging multi-omic technologies
  • Utilizes literature reviews, protocols, networking, and prior laboratory experience to advance the pre-clinical and clinical goals of the organization
  • Author research papers, abstracts, technical reports, and sections of regulatory documents
  • Effectively present and communicate research findings to internal and external collaborators, including upper management, regulatory agencies, and at research conferences
  • Collaborate with internal and external stakeholders
  • Other duties within the nonclinical development department, as assigned

Qualifications

  • Ph.D. in biology or associated life science discipline with strong background/experience in translational science
  • At least 10 years of relevant experience
  • Strong hands-on experience with translational lab methodologies (ex. cell-based techniques, ex-vivo drug testing and models, PK/PD assays)
  • Ability to collaborate and influence at all levels across an organization
  • Exceptional written and verbal communication allowing oneself to communicate scientific data and information to others in a digestible format
  • Analytical mindset and good problem-solving ability
  • Demonstrated ability to critically evaluate and contribute to multiple scientific programs
  • Diligence and attention to detail
  • Good organizational skills


EEO Statement

Verve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.

Recruitment & Staffing Agencies

Verve Therapeutics does not accept agency resumes unless contacted directly by internal Verve Talent Acquisition. Please do not forward resumes to Verve employees or any other company location; Verve Therapeutics is not responsible for any fees related to unsolicited resumes.

Job Summary

JOB TYPE

Full Time

INDUSTRY

Pharmaceutical

SALARY

$126k-163k (estimate)

POST DATE

04/04/2024

EXPIRATION DATE

06/03/2024

WEBSITE

vervetx.com

HEADQUARTERS

CAMBRIDGE, MA

SIZE

50 - 100

FOUNDED

2018

CEO

SEKAR KATHIRESAN

REVENUE

$5M - $10M

INDUSTRY

Pharmaceutical

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About Verve Therapeutics

Verve Therapeutics is a biotechnology company created with a singular focus: to protect the world from heart disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene editing, the company aims to develop transformative, once-and-done therapies for coronary heart disease. Verves gene editing medicines are designed to safely edit the genome of adults and mimic naturally occurring gene variants to permanently lower LDL cholesterol and triglyceride levels. The company is advancing a pipeline of precision genetic medicines, led by VERVE-101, which is being develo...ped initially for heterozygous familial hypercholesterolemia, a potentially fatal genetic heart disease. In 2020, Verve was recognized as a "Best Places to Work" by the Boston Business Journal and one of the "Endpoints 11." Verve is headquartered in Cambridge, Massachusetts. More
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