Research Specialist (Molecular and Cell Biology) - Chu Lab
University of California, San Francisco
Department of Urology
DESCRIPTION

The Chu Laboratory at the University of California, San Francisco, is seeking to recruit an outstanding candidate to fill a position at the Full Specialist level.

Research in the Chu Lab focuses on (1) identifying drivers of drug resistance in urologic cancer (bladder and prostate), (2) defining the role of the tumor immune microenvironment in facilitating treatment response, and (3) testing novel therapeutics in the perioperative setting. Our lab utilizes cancer genomics, cell biology, CRISPR screens, and in vitro and in vivo models to answer fundamental questions about tumor heterogeneity and evolution, with the goal of identifying new biomarkers and treatments. We work collaboratively with surgeons, basic scientists, computational biologists, pathologists, and oncologists at the UCSF Helen Diller Cancer Center across disciplines.

The role of the Specialist is to assist with ongoing experiments and, depending on the candidate's skill level, conduct independent research under the guidance of Dr. Chu and other members of the Chu Lab. The Specialist will learn and utilize a variety of research techniques and have the opportunity to be a co-author on publications.

Job responsibilities include but are not limited to:
* Performing a range of molecular biology techniques, including molecular cloning, DNA and RNA isolation, and protein expression analysis.
* Performing flow cytometry and immunohistochemistry experiments.
* Performing knock-down experiments using shRNA lentiviral infection and CRISPR-based techniques.
* Performing gene transfer studies using lentiviral infection of human cell cultures.
* Culturing primary human organoids and established human cancer cell lines.
* Assisting with mouse colony management, including breeding, weaning, tagging, and PCR genotyping.
* Conducting xenograft studies and pharmacologic experiments in mice.
* Assisting with lab maintenance duties.
* Assist in clinical trial development and execution.

Required qualifications:
* PhD in biomedical sciences or ten or more years of experience in the relevant specialization.
* At least 5 years of post-graduate lab experience
* Applicants need to be self-motivated, fast learners, critical thinkers, and enthusiastic about science and medicine.
* Applicants need to work well as part of a team and have outstanding written and oral communication skills.

Preferred qualifications:
* Prior independent research experience in molecular and cellular biology or tumor immunology.
* Experience with flow cytometry, mass cytometry (CyTOF), and/or immunohistochemistry.
* Experience with molecular biology and biochemistry techniques, cell culture, CRISPR/Cas9, qPCR, confocal microscopy, and/or managing a mouse colony.

Applicants will be considered until the position is filled. Please submit a curriculum vitae, cover letter, and provide a minimum of three names and email addresses of references from academic professionals supporting your research capability.

Salary and appointment will be commensurate with the applicant's experience and training. Applicants must possess the required qualifications by time of hire. This position is available immediately. Please apply online at https://aprecruit.ucsf.edu/JPF05096

See Table 24B for the salary range for this position. A reasonable estimate for this position is $86,900 - $181,800.

• 3 required (contact information only)

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

UC San Francisco seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.