About Sonoma Biotherapeutics:

Sonoma Biotherapeutics is a South San Francisco and Seattle-based company leading the development of adoptive Treg therapies cell for autoimmune and degenerative diseases. Using next-generation genome editing and target-specific cell therapy, Sonoma is focused on developing its best-in-class platform across the entire spectrum of Treg cell therapeutic capabilities. Founded by pioneers in Treg biology and cell therapy, the company brings together leading expertise and proprietary methodologies for the discovery and development of disease modifying and curative therapies. More information at www.sonomabio.com.

Job Purpose/Summary:

The Development Sciences group is in charge of nonclinical safety, pharmacokinetics, and immunogenicity assessments. We are seeking an independent and self-motivated Scientist to play a key role in the development of our cellular therapy pipeline projects. The candidate will aid in the lab-based preclinical assessments for IND and development-enabling studies and prepare and present findings to relevant teams. The ideal candidate should have a strong background in immunology and experience in cell culture and molecular biology lab techniques. Successful candidates will demonstrate creativity, critical thinking, and the ability to carry out independent and cross-functional teamwork, help develop new SOPs, and generate reproducible, high-quality data to inform development of Sonoma Biotherapeutics’ CAR T cell therapy platforms.

Roles and responsibilities:

• Conduct studies to assess the safety, pharmacokinetic, and immunogenicity potential of novel engineered regulatory T cell therapies.
• Culture and analysis of cell lines and primary cells (immune and non-immune) using various methods including but not limited to flow cytometry, molecular biology, and plate-based assays
• Work independently and in collaboration with other team members to design, carry out and analyze experiments
• Maintain accurate documentation of experiments in electronic lab notebook (ELN)
• Communicate data with team members and to others in organization
• Contribution to project teams as subject-matter expert or team representative

Qualifications and Education Requirements:

• PhD in immunology, cell biology, molecular biology or related field with demonstrated immunological expertise required. Additional postdoctoral or industry experience preferred.
• 0-5 years’ experience post-PhD
• Experience with multi-color flow cytometry setup and data analysis using FlowJo or other software
• Experience in other common immunological techniques (e.g. cytokine measurement by MSD/Luminex)
• Experience with cell culture of mammalian cells. Additional experience with primary human immune and non-immune cells preferred
• Demonstrated expertise in independent assay design and development
• Experience analyzing data using various software: Excel, GraphPad Prism, etc.
• Familiarity with literature-based research and ability to put data and information into context with respect to current scientific understanding
• Strong scientific understanding and critical thinking are required
• Excellent communication skills with demonstrated ability to present data and write reports
• Ability to adapt and work effectively in a team-oriented, collaborative environment

Preferred Skills:

• Experience with numerous assay types, particularly immune-based assays
• Additional familiarity with molecular biology techniques and assays preferred
• Prior experience working with human samples, particularly primary T cell culture
• Experience with Electronic Lab Notebook (ELN) systems and documentation
• Industry experience

Other duties:

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

Equal Employment Opportunity

At Sonoma Biotherapeutics, we believe that the highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse, and inclusive culture for all employees.

Sonoma Biotherapeutics is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other

characteristics protected under applicable federal, state and local laws.

We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply. Please submit your resume along with a cover letter to careers@sonomabio.com - resumes may also be submitted without

applying for a specific job.

If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process or are limited or unable to access or use this online application process and need an alternative method for applying, please contact us at careers@sonomabio.com