Scientist II – Senior Scientist PROTEIN BIOCHEMISTRY, PURIFICATION

April 2024

Department: Technology

Work Location: Corporate Headquarters (South San Francisco)

Position Summary

TCG Labs-Soleil is seeking an experienced and driven protein biochemist to join our growing multidisciplinary biologics Technology team. An instrumental member of the Protein Sciences group, this role will leverage strong expertise in protein purification, biophysical characterization, and biochemical modifications to contribute to the discovery and advancement of an exciting and innovative protein and antibody focused therapeutic pipeline. This candidate will have a ‘can-do’ attitude and work closely with scientists across research.

Responsibilities

• Responsible for design and execute purification strategies for recombinant proteins from a variety of host cells (mammalian, insect, and bacterial cells).
• Biophysical characterization of purified proteins using appropriate instrumentation.
• Troubleshoot and persevere on difficult projects to successful conclusions.
• Responsible for supporting the needs of multiple drug discovery projects and science objectives in parallel.
• Prepare precise technical summaries, protocols and maintenance of appropriate documentation.

Qualifications

• Ph.D. degree in biochemistry, molecular biology, structural biology or a related discipline with postdoc and 2-5 years relevant industry experience
• B.S. degree in biochemistry, molecular biology, structural biology or a related discipline equivalent industry experience.
• Strong experience in protein biochemistry, protein purification (using affinity and traditional chromatographic techniques), protein modification using enzymatic and chemical methods, and biophysical characterization.
• Hands-on, extensive experience with instrumentation essential for protein purification, especially AKTA FPLC and Agilent or Vanquish HPLC systems.
• Extensive experience with SDS PAGE or CE-SDS, Western blotting and other protein characterization techniques.
• Hands-on experience with small scale (milligram level) protein purification either via manual gravity or spin column or HTP automated chromatography method.
• Hands-on experience with large scale (gram level) endotoxin free production of antibody and protein therapeutics. 

• Familiarity of constructs design for challenging targets in various expression systems is desired, such as solid understanding of vector elements and utilization of solubility enhancing elements.

• Experience with successful purification of integral membrane proteins with working knowledge of detergents and NanoDiscs is desired.
• Hands-on experience with small to large scale production of protein conjugates is a plus.
• Must be able to thrive and deliver results on goals in a fast-paced, dynamic and highly multi-tasking environment.
• Must work well independently and as a member of teams in an inclusive manner.
• Must possess excellent communication and presentation skills.

Company Overview

TCG Labs-Soleil, established in partnership with The Column Group, a science-focused venture capital firm, is pioneering a novel ‘venture capital-biotech’ model. Our core mission is to efficiently translate scientific insights into therapeutic solutions for patients facing serious diseases. This model supports scientific entrepreneurs from the initial idea to clinical proof of concept (PoC) by combining a dedicated fund (TCG Labs) with our independent, evergreen R&D center led by a top-tier scientific team (Soleil). Together, we create an integrated ecosystem that fosters the development of single-asset portfolio companies, strategically poised for transacting after clinical PoC.

For more details, visit TCGLSoleil.com and follow us on LinkedIn

EEO Statement

TCG Labs-Soleil is an Equal Opportunity Employer. We do not discriminate against qualified applicants based upon any protected group status, including but not limited to race, religion, color, creed, sex (including breastfeeding and related conditions), gender identity/gender expression, pregnancy (including childbirth and related conditions), national origin, ancestry, age, marital status, military or veteran status, sexual orientation, genetic information, physical or mental disability or medical condition as defined by applicable equal opportunity laws. Any request for accommodation can be directed to contact@tcglsoleil.com. 

Benefits and Compensation 

TCG Labs-Soleil provides a competitive benefits package that includes access to Medical, Dental, and Vision Insurance, Life Insurance, Short and Long Term Disability, Health Savings Account (HSA), Flexible Spending Accounts (FSA), 401k plan and PTO.

The anticipated salary range for fully qualified candidates applying for this role will be $105,000 - $187,500 annually (not including discretionary bonus, equity, and benefits). The final salary offered will be dependent on several factors that include but are not limited to relevant previous experience including duration and type of experience within the industry, education, and internal equity.

Staffing Agencies

TCG Labs-Soleil does not accept unsolicited agency resumes and will not pay fees to any third-party agency or firm that doesn’t have a signed agreement with TCG Labs-Soleil. Please do not send agency CVs/resumes through TCG Labs-Soleil website or TCG Labs-Soleil Employees. Inquiries must be sent to contact@tcglsoleil.com with the Subject Heading: Staffing Agency Request.