Overview

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. These values are grounded in and expressed through the principles of diversity, equity and inclusion. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an anti-racist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, anti-racism and inclusion.

The Nabet laboratory is seeking a bright and highly motivated Research Technician I II to provide high-leveltechnical support for ongoing research efforts . The goals of our research program are to develop strategies to target cancer drivers by controlling protein homeostasis to gain new biological insights into clinically relevant targets and to advance new therapeutic strategies in cancer. The Nabet laboratory develops and deploys innovative chemical biology technologies such as the dTAG system to rapidly eliminate target proteins for therapeutic target discovery and validation ( Nabet et al., Nature Chemical Biology 2018 ; Nabet et al., Nature Communications 2020 ). The Nabet laboratory is highly collaborative and works extensively with medicinal chemists in academia and industry to develop inhibitors and degraders for cancer drug targets ( Koide et al., ChemBioChem 2023 ; Li et al., European Journal of Medicinal Chemistry 2022 ). We are committed to supporting the next-generation of scientists and believe in collaborative science ( Nabet, ChemBioChem 2021 ) . This is an exceptional opportunity to join a team that is pushing the boundaries of cancer chemical biology.

Responsibilities

This position will work under the Principal Investigator and with the lab tocontributeto boththe conceptual andtechnicalaspects ofthe project. The candidate willbecome involved with all the steps of research being completed by the group, and willwork independently and part of a dynamic team. The candidate will develop engineered cancer model systems using the dTAG technology platform as well as high-throughput screening systems to evaluate small molecules.The candidate will execute experiments as part of collaborative projects with academia and industry.The candidate will also perform lab managerial duties including the set-up, operation and maintenance of laboratory instruments and equipment, order and maintain appropriate levels of supplies, andmay supervise and train students. Additional responsibilities include:

• Chemical biology techniques including assays to evaluate small molecules including target engagement and target degradation.

• Cell and m olecular biology techniques including western blotting, immunoprecipitation, cloning, PCR, qPCR, sterile tissue culture, virus preparation, DNA/RNA isolation, CRISPR/Cas9-mediated genome editing, flow cytometry, and cell sorting.
• Murine modeling work including animal handling, compound administration, and dissection.
• Monitor and order supplies for the lab.
• Maintain organized and complete lab records and inventories.
• Train new lab members and supervise students.

• Use computers, computer-interfaced equipment, robotics, or high-technology applications to perform work duties as well as equipment that requires setup, calibration, maintenance, and troubleshooting.
• Analyze and interpret experimental data and summarize findings for presentations , grants , pre-prints, and publications .
• Provide intellectual and interactive commitment to the position by keeping up with appropriate literature and research publications.

Qualifications

MINIMUM QUALIFICATIONS:

• Senior level position requiring extensive experience in a laboratory.
• Master’s degree in biology, chemical biology, molecular biology, biochemistry, chemistry, or related field .

PREFERRED QUALIFICATIONS

• The ideal candidate will be meticulous, self-driven, and excited to participate in this critical work.
• Highly motivated and intellectually curious.
• A solid background knowledge in cell and molecular biology, chemical biology, or cancer biology.
• Experience with standard laboratory techniques such as tissue culture, western blotting, immunoprecipitation, extraction and analysis of DNA and RNA, PCR, and cloning.
• Experience in bioinformatics and/or mouse modeling is a plus.
• Interact well with team members to execute experiments and collaborators to interpret data.
• Experience training others on general lab experiments.
• Excellent written and verbal skills.
• Exceptional attention to detail and thorough in completing work tasks.
• Experience keeping meticulous records on experiments and protocols.
• Ability to maintain an organized laboratory notebook and computer files with a working knowledge of data management, word processing, and graphic software ( e.g. Microsoft office, Graphpad /PRISM).

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

The annual base salary range for this position is from $67,716 to $99,236, and pay offered will be based on experience and qualifications.

This position may be eligible for relocation assistance .

Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, tuition reimbursement, paid vacation (12-22 days per year), paid sick leave (12-25 days per year), paid holidays (13 days per year), paid parental leave (up to 4 weeks), and partially paid sabbatical leave (up to 6 months).