Organization Overview:
RNA is the driving force of biological complexity, determining which genes any given cell expresses at specific times and under specific circumstances. Darnell developed high-throughput sequencing and crosslinking methods to investigate how RNA binding proteins (RBPs) modulate gene expression. He discovered neuron-specific RNA-binding proteins in the mammalian brain, and studies their link to intellectual function and human disease.
Overview:

Our group focuses on characterizing the molecular mechanisms that underlie phenotypes of rheumatoid arthritis (RA). In previous studies we have used machine learning to integrate rheumatoid arthritis gene expression profiles with synovial histology features to provide insight into RA disease subsets (Arthritis and Rheumatol, 2018). We noted the persistence of histologic and transcriptional evidence of subclinical synovial inflammation in some RA patients in clinical remission (Arthritis and Rheumatol, 2019). Our group has also uncovered synovial histology associations of morning stiffness (Arthritis and Rheumatol, 2020). We have developed methods to empower patients to participate in dense longitudinal genomics studies from home and used this approach to gain insights into the immune events that lead to rheumatoid arthritis flares (NEJM, 2020).

Responsibilities:

Responsibilties include:

• Helping to collect, store, process and organize clinical blood and tissue samples
• Using basic molecular biology and biochemical techniques including:
  • PCR
  • RNAseq library preparation
  • flow cytometry and sorting
  • immunofluorescence

Qualifications:

Required:

• Bachelor's degree, with educational emphasis in Life sciences, molecular biology or biochemistry
• Background knowledge of molecular biology is preferred
• Basic knowledge of tissue culture and laboratory practice
• An ability to give full attention to experiments and keep accurate and accessible records

The Rockefeller University does not discriminate in employment on the basis of race, color, religion, sex (including pregnancy, gender identity), national origin, political affiliation, sexual orientation, marital status, disability, genetic information, age, membership in an employee organization, retaliation, parental status, military service or other non-merit factor. All qualified applicants will receive consideration for employment without regard to the characteristics listed above.

The salary of the finalist selected for this role will be set based on various factors, including but not limited to organizational budgets, qualifications, experience, education, licenses, specialty, and training. The hiring range provided represents The Rockefeller University's good faith and reasonable estimate of the range of possible compensation at the time of posting.

Compensation Range: Min:
USD $48,300.00/Yr.
Compensation Range: Max:
USD $52,000.00/Yr.