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Roche Diagnostics acquired Stratos Genomics (https://www.stratosgenomics.com/) in 2020 for its unique chemistry that advances DNA sequencing by nanopore, Sequencing by Expansion (SBX™). You will engineer and synthesize the molecular building blocks for our novel technology. These building blocks translate DNA sequences into a simple to measure surrogate, the Xpandomer, which significantly improves the accuracy and throughput of nanopore sequencing.

The Molecular Engineering group is passionate about the novel molecules they have developed and the impact SBX technology can have on advancing sequencing and patient outcomes. We are looking for people who are excited about the significance of our technology and want to make SBX successful.

The Opportunity:

• To research, design and execute innovative experiments

• Identify and troubleshoot problems in creative ways

• Contribute to the definition and timely achievement of project goals

• Participate in the production of reagents and starting materials

• Develop SOPs for production materials

• Perform data analysis and protocol development

• Maintain accurate, detailed and reliable laboratory records

• Present findings at group or departmental meetings

• Maintain the lab’s cleanliness and organization

• Develop and propose improved processes to fulfill the above functions.

Who You Are:

• You have a deep interest or technical background in next-generation DNA sequencing

• You have a minimum of 2 years laboratory experience in advanced oligo synthesis (e.g. use and development of non-standard phosphoramidites and reagents, branched or cyclic structures, and instrument modification)

• You have demonstrated ability to understand and develop novel chemistry for automated oligo synthesis:

  • Create new chemistry for detritylation, coupling, capping and oxidation

  • Able to manipulate and engineer novel solutions with complex automated fluidics (i.e. Automated Oligo Synthesizers)

• You have a mature understanding of how to work with chemical and biochemical samples, including sample handling, reactivity, purification and storage.

• You have comprehensive experience with HPLC, MS, NMR, inert atmosphere chambers, and manual pipetting.

• You hold a Bachelor’s degree in Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry or related field; or equivalent combination of education and work experience, MS or PHD

Preferred :

• 5 years of experience, less with advanced degrees.

***Please include a cover letter outlining why you want to work with us, your specific interest in SBX technology (technical) and how you would contribute, this is important.***

Relocation benefits are available for this posting.

The expected salary range for this position based on the primary location of Seattle, WA is $87,500 and $162,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed here: Benefits

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual’s race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.