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Manufacturing Science and Technology Associate Director

Apply locations Boston, MA time type Full time posted on Posted 3 Days Ago job requisition id REQ-22079

Job Description

The Associate Director, Manufacturing Science and Technology (MSAT) – Materials Science will support the Vertex Cell and Gene Therapy (VCGT) manufacturing network by applying a deep understanding of relationships between materials properties, process conditions, and final product quality. The role will have a proven track record of applying in-depth conceptual knowledge of materials science and engineering principles to materials and improved process understanding , with in-depth knowledge of one or more relevant areas applicable to cell and gene therapies.

Key Responsibilities:

• Represent the MSAT function in cross-functional teams as a materials science leader for single-use systems, cell culture media, cytokines, and/or small/large molecule raw materials.

• Support and champion continuous improvement and technical innovation within the VCGT network with respect to raw materials.

• Establish procedures and business processes to conduct raw material technical assessments, support onboarding new materials and technologies, alternate material sources, as well as supplier-initiated material change notifications.

• Demonstrates unmistakable intellectual and/or technological leadership on material science projects.

• Collaborate with risk management and program management functions to articulate technical risks and develop/manage mitigations.

• Liaise with technical leads from other programs and functions to build collective cell and gene therapy knowledge.

• Engage industry to identify best practices and improvement opportunities.

Minimal Requirements :

• Requires 6-8 years of relevant experience in the biopharmaceutical industry or the equivalent combination of education and experience.

• Advanced degree (MS/ Ph.D./ Eng Doc) in Science/Engineering or equivalent is essential.

• Deep knowledge of cell culture media formulations and manufacturing, single-use-systems, and small/large molecule materials.

• Previous experience working in a highly matrixed environment.

• Extensive experience with biologics process development and cGMP manufacturing.

• Experience with cGMP regulations/guidance and regulatory agency inspections.

• Experience authoring/reviewing CMC product submissions and post-approval changes.

• Experience with continuous improvement, proficiency with operational excellence preferred.

• Experience working with external manufacturing partners (CDMOs), suppliers, and service providers.

• Ability to travel, nationally and internationally, up to 10%.

• Flexibility to work on site a minimum of 3 days per week.

Vertex is a global biotechnology company that aims to discover, develop and commercialize innovative medicines so people with serious diseases can lead better lives. In addition to our clinical development programs focused on cystic fibrosis, Vertex has more than a dozen ongoing research programs aimed at other serious and life-threatening diseases.

Founded in 1989 in Cambridge, Mass., Vertex today has research and development sites and commercial offices in the United States, Europe, Canada and Australia. For four years in a row, Science magazine has named Vertex one of its Top Employers in the life sciences. For additional information and the latest updates from the company, please visit www.vrtx.com .

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.

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Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency .

Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook , Twitter/X , LinkedIn , YouTube and Instagram .

The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. 

Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.

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