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Orion
Worcester, MA | Full Time
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Scientist II
Orion Worcester, MA
$115k-142k (estimate)
Full Time | IT Outsourcing & Consulting 0 Months Ago
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Orion is Hiring a Scientist II Near Worcester, MA

Job description

Scientist II - New Biologics Developability Screening: Analytical and Formulation Development
Worcester, MA
12 month contract
Hourly Rate: $44-48/hr
Orion Group is seeking for an analytical-minded individual to work as a Scientist with our global pharmaceutical client in Worcester, MA. This exciting contract opportunity has the possibility to be extended or converted into a permanent position for the right person.
Responsibilities:
  • Conduct laboratory-based analytical biochemistry and formulation development activities with Biologic drug candidates.
  • Develop fit-for-purpose methods for analytical characterization.
  • Conduct experiments to evaluate physicochemical properties of new biologic entities (monoclonal antibodies, bispecific antibodies, antibody drug conjugates, fusion proteins, AAV etc.) for potential liabilities that could impact drug development.
  • Independently execute experimental protocols and SOPs, collect results, and perform data analysis. Document studies and report results in group and cross-functional meetings.
Requirements:
  • BS, MS, or PhD in Biophysics, Bioengineering, Chemical Engineering, Biochemistry, Pharmaceutical Sciences or related field with 3 (BS), 1 (MS), or 0 (PhD) years biopharmaceutical industry preferred.
  • Hands-on experience in protein biochemical/biophysical characterization, formulation development, analytical method development. Strong background in protein analytical development, protein stability, degradation pathways and formulation development.
  • Expertise in protein biophysical/biochemical characterization, including spectroscopy (UV-Vis, CD, analytical ultracentrifugation, fluorescence), chromatography (size exclusion, ion-exchange, reverse phase, hydrophobic interaction chromatography), electrophoresis (icIEF, CE-SDS), differential scanning calorimetry/fluorimetry, viscosity, light scattering techniques (DLS, SLS) and subvisible particle characterization. AAV and other viral gene therapy analytical experience is desired. Must be willing to learn new techniques as needed.
  • A self-motivated and effective team member with excellent oral and written communication skills.
What are the top 3-5 skills/requirements this person is required to have?
  • Ability to calculate concentrations of active and secondary components, convert between units and prepare solutions as needed. Measure and calculate protein concentration given an extinction coefficient using spectrophotometry. Understand Beer's Law and interpret absorbance spectrum.
  • Understand protein stability and degradation pathways.
  • Required Skill 3: Understand the principles of chromatography. UPLC/HPLC hands-on experience (size exclusion, ion-exchange, reverse phase, hydrophobic interaction chromatography).
  • Ability to use Excel, PowerPoint, and other analysis software for basic statistical calculation and data analysis.
  • Lab work experience
What is a nice to have (but not required) regarding skills, requirements, experience, education, or certification?
  • AAV and other viral gene therapy characterization experience.
What is the environment that this person will be working in (i.e. group setting vs. individual role)?
  • Independently but in a group setting.

Our role in supporting diversity and inclusion
As an international workforce business, we are committed to sourcing personnel that reflects the diversity and values of our client base but also that of Orion Group. We welcome the wide range of experiences and viewpoints that potential workers bring to our business and our clients, including those based on nationality, gender, culture, educational and professional backgrounds, race, ethnicity, sexual orientation, gender identity and expression, disability, and age differences, job classification and religion. In our inclusive workplace, regardless of your employment status as staff or contract, everyone is assured the right of equitable, fair and respectful treatment.

Job Summary

JOB TYPE

Full Time

INDUSTRY

IT Outsourcing & Consulting

SALARY

$115k-142k (estimate)

POST DATE

05/20/2023

EXPIRATION DATE

06/06/2024

WEBSITE

orioninc.com

HEADQUARTERS

EDISON, NJ

SIZE

1,000 - 3,000

FOUNDED

1993

CEO

ANTHONY MITCHELL

REVENUE

$50M - $200M

INDUSTRY

IT Outsourcing & Consulting

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About Orion

NetRD Bilgi Teknolojileri ve Telekomnikasyon A.S, is now part of Orion Innovation Group... Orion is a leading digital transformation and product development services firm that provides business solutions rooted in Digital Strategy, Experience Design, and Engineering, delivering transformative business transformation and product development for our clients. With a unique combination of agility, scale and maturity, Orion is headquartered in Edison, NJ and has a team of over 4,750 associates in 9 major delivery centers across the Americas, Europe, and APAC. Our mission is to be an agile and trust...ed partner for business transformation initiatives, providing deep emerging technology, digital design and domain expertise. Orion has served Fortune 1,000 enterprises for over 25 years with clients across financial services, professional services, telecommunications and media, automotive, industrial automation, professional sports and entertainment, life sciences, ecommerce and education. The Wall Street Journal recently spoke to Raj and published a story on the recent acquisition of Tekmark Global Solutions. Read the article here: https://webreprints.djreprints.com/57342.html More
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