OUR VALUES: PASSION: We are driven and love what we do. We are committed to our goals and to making a difference. INTEGRITY: We do the right thing for patients and our community. We take accountability. We speak up. COLLABORATION: We trust one another. We are inclusive. We are respectful. We are transparent. Together we succeed. INNOVATION: We seek and create optimal solutions. TENACITY: We do not quit. We adapt. We accomplish what others cannot. Come join our team during this exciting time of growth and opportunities! We are a top place to work. Neurocrine Biosciences was named one of the FORTUNE Best Workplaces in Health Care and Biopharma™ 2021, ranking No. 4 among biopharma companies. In addition, we were also selected as one of the FORTUNE Best Small & Medium Workplaces™ 2020 and 2021 lists, ranking No. 8 and No. 7 out of 100 medium-sized companies across the country. We were also named a Great Place to Work Certified company and were recognized on Great Place to Work’s Best Workplaces for Parents™ 2020 list. ©2020 FORTUNE Media IP Limited. All rights reserved. Used under license. ©2021 FORTUNE Media IP Limited. All rights reserved. Used under license. Who We Are: At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options. What We Do: Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson’s disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *in collaboration with AbbVie About the Role: The Scientist, Antibody Engineering will conduct laboratory activities related to antibody engineering including cloning, mutagenesis, library construction and variant screening. The ideal candidate will have extensive hands-on experience working on therapeutic antibody optimization preferably in a biotechnology or pharmaceutical company setting. The person in this role will support protein engineering in all areas of early-stage antibody optimization for Neurocrine’s biotherapeutic pipeline. _ Your Contributions (include, but are not limited to): Neurocrine is building a team of talented scientists with proven track records to drive therapeutic pipeline progression from discovery to lead selection within a cutting-edge antibody engineering group We are seeking a lead molecular biologist/protein engineer responsible for construct design, molecular cloning, multi-piece DNA assembly, site-directed mutagenesis and preparation of libraries Responsibilities include generating and screening site-directed, CDR randomization and combinatorial antibody libraries for affinity maturation and developability optimization Critical member of the team contributing to characterizing antibodies and antibody-based therapeutics (for e.g. affinity, specificity, cross-species binding, epitope determination) Will be involved in the engineering of advanced modalities such as bispecific antibodies Contribute to the design and cloning of antigens Responsible for understanding experimental data from multiple sources, forming hypotheses, devising strategy and implementing prioritization Contribute to the evaluation of emerging molecular biological or biochemical methods, initiate and support new platforms, instrumentation and technologies for antibody engineering Working cross-functionally with protein biochemists, cell biologists and gene therapists to achieve projects goals Requirements: BA/BS in Molecular Biology, Biochemistry or other relevant discipline and 5 years of Biotechnology industry experience in antibody or protein engineering OR Master's degree in Molecular Biology, Biochemistry or other relevant discipline and 3 years of similar experience noted above OR PharmD or PhD in Molecular Biology, Biochemistry or other relevant discipline; may include postdoc with relevant experience noted above Experience with routine antibody cloning Hands-on experience in the design and execution of antibody optimization campaigns using directed evolution screening platforms such as capture-lift, phage display or yeast display a plus Demonstrated mastery of standard molecular biology bench skills, DNA sequence analysis and software, oligo design coupled with strong desire to work in the laboratory Experience with standard laboratory instrumentation: PCR, centrifugation, DNA quantitation, gel documentation systems, plate readers and washers, liquid handling, etc. Familiarity with affinity determination methods (e.g. ELISA, MSD, Octet, Carterra, Biacore or Kinexa) Ability to maintain detailed experimental documentation Excellent communication and interpersonal skills with an ability to work both independently and in a team environment Proficiency in Microsoft Office and DNA sequence analysis software such as Sequencher, Geneious or SnapGene Experience with various antibody formats including Fab, scFv, IgG, nanobody and multi-specific derivatives a plus Knowledge of standard antibody assay and cloning reagents and preferred vendors Experience with small scale antibody expression/purification a plus Experience doing small scale tissue culture and running ADCC, ADCP, CDC and cell-based reporter assays a plus #LI-AD1 Neurocrine Biosciences is an EEO/AA/Disability/Vets employer. As a condition of employment with Neurocrine Biosciences, Inc. in the United States, you must be fully vaccinated for COVID-19 and provide valid proof of vaccination to the company.