We are hiring a Manager, Plasmid Process Development, to develop and lead Metagenomi’s plasmid production processes. Reporting to the Director, Process Engineering,this position is responsible for tracking lots, drafting budgeting forecasts, managing plasmid/mRNA requests from other functional areas, and trending relevant data to propose optimizations to the process for improved purity, scaling up to enable GMP plasmid production in-house, further bolstering our mRNA capabilities. The role is based in Emeryville, California. 

How you’ll contribute: 

• Partner with technical operations to manufacture plasmid to support the mRNA-based gene editing systems, including bacterial transformation, colony selection, cell banking, fermentation, harvest, chromatography, TFF, linearization, polishing, and functional testing for mRNA production. 
• Support RNA synthesis by in-vitro transcription and nucleic acid purification
• Support nucleic acid characterization with UV absorbance, PCR, capillary/gel electrophoresis
• Determine Critical Process Parameters(CPPs) and partner with Metagenomi’s Analytical team to define Critical Quality Attributes (CQAs)
• Support process optimization efforts, improving robustness and quality of mRNA and plasmid
• Draft experimental protocols, technical reports, Batch Records, SOPs, and material specifications
• Support technology transfers and engineering runs
• Contribute to root cause analyses for deviations and CAPAs
• Provide general laboratory assistance, including lab equipment maintenance, ordering of lab supplies, preparation of reagents, and compliance with safety policies

Must haves: Knowledge, Skills, Abilities:

• Undergraduate degree, advanced degree preferred in Molecular Biology or a closely related discipline 
• At least 10 (B.S.), 6 (M.S.), 3 (Ph.D.) years of industry experience in Research or Process Development 
• Experience with TFF, Akta Pure/Avant, and Chromatography systems for mRNA and plasmid
• Nucleic acid characterization with UV absorbance, PCR, capillary/gel electrophoresis
• Experience with LNPs and downstream activities 
• Project Management and team leadership experience
• Extremely organized and able to efficiently manage your time and workflow, including skillfully prioritizing long-term projects and day-to-day responsibilities.

California Pay Transparency Disclosure:

Under the Federal Labor Standards Act, this position is classified as exempt. Its anticipated base salary range will be $130,000 to $170,000. Depending on the position offered, you will also be eligible to receive equity, bonuses, and a full range of benefits. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on location, skill level, years and depth of relevant experience, and education. 

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