The Opportunity
insitro is pioneering a new approach to drug discovery and development, enabled by the use of advanced machine learning (ML) to interrogate large amounts of cellular, molecular and clinical data. One of insitro's important platforms is the use of proprietary DNA-encoded chemical libraries and selection technologies, combined with ML, for small molecule drug discovery in neurology, oncology and metabolic disease.
We are seeking an experienced chemistry leader, who will guide our molecular strategies using DEL data, and advanced ML to accelerate and increase the success of our preclinical programs. Reporting to the VP, High-Throughput Chemistry in the Therapeutics team, you will manage a small team of DEL scientists at the intersection of target biology and Medicinal Chemistry and Data Science, with the intent of advancing breakthrough therapies for patients in need. You will work onsite at our headquarters in South San Francisco, CA.
Responsibilities

• Support the DEL team in the design of DEL selections/screens and the prioritization of DEL hits for resynthesis and testing
• In partnership with Medicinal and Computational Chemistry, you will guide the design of built-for-purpose DELs to explore property and biology space and develop SAR insights.
• Oversee the synthesis of DEL hits internally and at CRO's and lead teams in the prosecution of drug discovery campaigns
• Collaborate with Data Science/ML in modeling the design, screening, and analysis of DELs
• Promote communication between the DEL- ML platform and the Therapeutics team

About You
Scientific Experience

• BS with 14 years of experience, MS with 12 years of experience, or Ph.D. in synthetic organic chemistry, medicinal chemistry or computational chemistry with 9 years of industrial drug discovery experience
• Passionate about pushing the boundaries of drug discovery with Machine Learning and DNA-Encoded Libraries
• Experience advancing projects through stages of drug discovery in several therapeutic indications
• Experience managing scientific collaboration and CRO resources
• Record of peer-reviewed publications/patent applications

Leadership/Personality Traits

• Data-driven, quantitative mindset, and experience collecting and utilizing data in drug discovery
• 3 years of leadership experience with DNA-Encoded Libraries
• Experience leading a diverse, inter-disciplinary team

Compensation & Benefits at insitro
Our target starting salary for successful US-based applicants for this role is $245,000-$275,000. To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
In addition, insitro also provides our employees:

• 401(k) plan with employer matching for contributions
• Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees on our base plans), as well as mental health and well-being support
• Open, flexible vacation policy
• Paid parental leave
• Quarterly budget for books and online courses for self-development
• Support to attend professional conferences that are meaningful to your career growth and role's responsibilities
• New hire stipend for home office setup
• Monthly cell phone & internet stipend
• Access to free onsite baristas and cafe with daily lunch and breakfast
• Access to free onsite fitness center
• Commuter benefits

insitro is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams-grounded in a wide range of expertise and life experiences-and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.
#LI-Onsite
About insitro
insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitro's approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit www.insitro.com.