The Opportunity

The heart of insitro's strategy is the combination of advanced machine learning, biology at scale and molecular discovery that address bottlenecks in the drug development pipeline. To accomplish that, we are putting together an incredible team with a passion for target discovery and therapeutics advancement.

Reporting to the Oncology Discovery Therapeutic Area head, you will partner with data science and machine learning (DSML), translational oncology and computational biology colleagues to gain deep insights into the biology and efficacy of antibody drug conjugates (ADCs) with the goal of delivering therapeutics to the right patients. You will lead studies to validate ADC targets, evaluate linker and warhead strategies and support biomarker development.

This will be a hybrid on-site/remote preclinical role, with opportunities to lead projects to drug candidate nomination. You are collaborative, creative, and rigorous and will excel in an exciting environment. This is an excellent opportunity for someone passionate about therapeutic discovery and making an impact on cancer patients!

You will join a growing techbio startup that has long-term stability but is very much in formation, providing many opportunities for impact. You will work with an accomplished versatile team with learning opportunities, and help shape insitro's culture, strategic direction, and outcomes. Join us, and help make a difference to patients!

Responsibilities

• Lead efforts to evaluate ADC targets with the goal of producing viable therapeutic interventions, including target prioritization and evaluation of linkers and payloads
• Oversee studies aimed at generating datasets to inform machine learning models of tumor ADC sensitivity
• Lead preclinical validation of prioritized ADC antibody-linker-warhead combinations in cells and tumor models
• Collaborate with external acceleration partners in efforts related to insitro's ADC program
• Provide ADC biology expertise including strategic, scientific and technical mentorship to shape insitro's ADC portfolio

About You

• PhD in a biological science related field (Cell bio, Biochem, Genetics etc.) with 8 years of industry experience including 5 years in ADC target or therapeutic discovery and/or development
• Understanding of ADC components, construction and mechanisms of action
• Record of leading project teams
• Experience managing CROs and collaborating with external partners
• Experience working with data scientists / computational biologists /statistical geneticists

Compensation & Benefits at insitro

Our target starting salary for successful US-based applicants for this role is $175,000 - $195,000. To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.

This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

In addition, insitro also provides our employees:

• 401(k) plan with employer matching for contributions
• Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees on our base plans), as well as mental health and well-being support
• Open, flexible vacation policy
• Paid parental leave
• Quarterly budget for books and online courses for self-development
• Support to occasionally attend professional conferences that are meaningful to your career growth and development
• New hire stipend for home office setup
• Monthly cell phone & internet stipend
• Access to free onsite baristas and cafe with daily lunch and breakfast
• Access to free onsite fitness center
• Commuter benefits

insitro is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We strive to bring together diverse teams–grounded in different expertise and life experiences–and ensure those teams succeed in inclusive, growth-oriented environments supported by equitable company and team practices. You can expect equitable treatment, respect, and fairness throughout the interview process.