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The Immunogenicity Department in Biomarkers and Bioanalytical Platforms provides analytical support and expertise for biotherapeutic programs in clinical development. Our scientists develop and validate clinical assays to detect and characterize immune responses that might arise against the biotherapeutics. Assays are validated and include ligand binging and cell-based platforms, informing potential impacts on drug pharmacokinetics, safety and efficacy.
We are looking for an intern to help us evaluate the impact of acid dissociation treatment on therapeutic and control antibodies in an immune complex model. We develop competitive ligand binding methods to identify neutralizing antibodies against our drugs using electrochemiluminescence readouts. In addition to these methods, the co-op would also use biochemical and biophysical characterization methods such as surface plasma resonance (SPR) and biolayer interferometry (BLI) to measure the interactions between the drug and the antibodies. The successful applicant would learn these techniques and more as we identify ways to study these interactions.
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Intern
$59k-75k (estimate)
03/27/2024
04/28/2024