Principal Oligo Data Scientist

The oligotherapy principal data scientist role is embedded in and directly supports the Oligo Sciences team whose broad remit is the design, characterization, and early development of oligonucleotide therapies. Oligo data scientists will serve a dual purpose of co-developing a data capture & analysis platform with oligo sciences experts and translating their needs broadly across GSK to build methods/models/capabilities that fulfil them.

Key Responsibilities:

• Co-design and implement a target tractability system for oligo-guided therapeutic mechanisms such as RNA degradation/interference, and up/down modulation of alternative splicing, poly-adenylation, A>I editing, etc.
• Co-develop a target/complex engagement model that combines target sequence, secondary tertiary structure, and oligo chemistry to drive binding assay designs for both high-throughput screening and low-latency optimization.
• Collaborate effectively with renowned GSK experts in genetics, genomics, computational bio & chem, structural biology and medicinal chemistry, artificial intelligence / machine learning, and digital technologies to build the datasets, tools, models, and infrastructure necessary for oligo design & development.

Basic Qualifications:

• MS degree in computational life science (bio/med/chem/stats/informatics) with at least 1 published work and at least 5 years of industry experience

• Over 1 year experience with genomic data infrastructure for either public or private collections (e.g. ENCODE, TCGA, DepMap, GTEx, cellXgene, UK biobank)

• Over 1 year experience with Cheminformatic or structural modelling of drug-target binding for small or large molecules validated by real qSAR assays

Preferred Qualifications:

• PhD degree in computational life science (bio/med/chem/stats/informatics) with at least 1 published work

• Demonstrated cross-functional communication, matrixed collaboration, both team and thought leadership

• Performed target identification or tractability/prioritization for RNA-modulating approaches or RNA-targeted modalities

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