GlaxoSmithKline (GSK) is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

Biopharm Process Development is a highly experienced Chemistry, Manufacturing and Controls (CMC) organization accountable for delivering robust, cost effective and competitive products and manufacturing processes spanning the full life-cycle of asset development from discovery through commercialization. These activities are delivered through state-of-the art internal facilities as well as strategic external partners. Collectively, the team is accountable for CMC activities encompassing cell line development, cell culture / microbial fermentation, purification development, and drug product / device development. We also pioneer innovative technologies to improve robustness, reduce cost of goods, and improve the patient experience.

Within Biopharm, Upstream Process Development is responsible for bioreactor based cell culture processes with line of sight to manufacture of GSK's Biopharm assets. The Department is also responsible for the scale-up and tech transfer of the processes to manufacturing facilities all over the world. Our aim is to integrate innovative expression and process platforms, automation, and advanced data analytics into the upstream process development workflow. An opportunity has arisen for an upstream process development scientist to advance our automation capabilities and handle large sets of complex data. They will have the opportunity to develop new methods and build capability in automated workflows and data handling.

In this role, you will be a member of a highly skilled team of scientists and engineers responsible for development and optimization of bioprocesses employing ambr (advanced microscale bioreactor) technology, integrated analytical instrumentation and data management. Although predominantly lab-based, the role also involves important aspects of verbal and written communication and requires good organisation skills as well as a broad scientific knowledge of cellular metabolism and physiology. You will be working in a matrix team and therefore the role will suit a scientist with excellent interpersonal skills, the ability to solve real-time complex problems, strong self-motivation and an open mindset. As bioreactor processing is a 24/7 operation, some preplanned well-balanced off hours work is typically necessary.

Key responsibilities include:

• Become proficient in ambr250 operation and troubleshooting, including software, hardware and integrated analytical instruments.
• Provide technical support and expertise for execution of fed-batch and perfusion-based cell culture processes on the ambr platforms.
• Ensure ambr platforms are in good working order at all times. Manage run scheduling, consumables inventory, repairs/maintenance, and general laboratory upkeep and organization.
• Actively participate in expansion and enhancement of system capabilities
• Team-based and independent execution of ambr bioreactor studies for development and optimization of cell culture processes, evaluation for facility fit, and small-scale model qualification.
• Interact with colleagues in key partner groups: scientists/engineers involved in upstream process scale-up and tech transfer, downstream process development and analytical method development scientists, data scientists and statisticians.

We are looking for professionals with these required skills to achieve our goals:

• Bachelor's or Master's degree in Bioprocess/Biochemical/Chemical Engineering or related Biological Science.
• Experience in routine bioreactor operation, cell culture and aseptic technique.
• Experience working in a biological laboratory and familiarity with general laboratory procedures.

If you have the following characteristics, it would be a plus:

• Proficiency with operation and troubleshooting ambr250 HT & Perfusion platforms, Flex2, ViCell XR, Blu and Raman.
• Solid theoretical background in cell biology and physiology.
• Writing and reviewing technical documents with a basic understanding of regulatory requirements
• Programming experience (e.g. Python, Spotfire, Visual Basic, etc)
• Statistical analysis
• Excellent interpersonal and communication skills
• Ability to adapt quickly to new scientific areas and work across teams.

Please visit to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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