The Company: 

WHAT IF THE SECRET OF HEALTH LIES AT THE CENTER OF DISEASE? At Sonata Therapeutics, we are designing Network Medicines(TM)that reprogram diseased cells to become the coordinators of cure. 

Through a combination of our proprietary genetic library, comprehensive biochemical and functional characterization, and the latest advancements in machine learning algorithms, we are generating a deep understanding of how to reshape multicellular networks to guide the development of transformative therapeutics. While initially focused on oncology, our network-based approach is applicable across many intractable diseases.

Sonata Therapeutics was founded by Flagship Pioneering, an organization dedicated to the origination and development of first-in-category life sciences companies. Since 2000, Flagship has originated and fostered the development of nearly 100 scientific ventures resulting in $20 billion in aggregate value, 500 issued patents, and more than 50 clinical trials for novel therapeutic agents.

The Position

Due to our success, we are currently on the hunt for a creative, collaborative, Scientist I or II to support the development of new Network Medicines(TM). This individual will work across a matrixed organization to advance programs from lead optimization through IND-enabling activities, with the ultimate goal of demonstrating thereapeutic Proof-of-Concept in the clinic.

As a Scientist I or II, you will be a key contributor in exploring novel target mechanisms and developing novel small molecule Network Medicines(TM). You will be an ambitious and collaborative scientist with a strong background in cell & molecular biology. We are searching for enthusiastic, innovative, and highly motivated individuals who are comfortable working in a fast-paced entrepreneurial environment.

Sonata Therapeutics offers the challenge and opportunity to work at an early-stage, big concept biotechnology company. Your efforts will directly impact the expansion of our R&D portfolio, including existing, early-stage research programs as well as first-in-human clinical studies within the next 18 months that will lead to the development of new, life-changing, innovative therapies. 

You will be making a significant impact by...

• Designing and implementing experimental plans for validation of novel targets in various disease areas to expand our understanding of therapeutic mechanisms-of-action and future strategies as the program evolves and progresses forward.
• Engineering and maintaining cell lines to support validation of our lead drug candidates and subsequent indication selection activities
• Developing and performing a variety of novel cell-based assays to identify and understand important phenotypes
• Designing in vivo studies and performing disease-relevant ex vivo sample analyses
• Working closely with multi-disciplinary project and program teams and presenting high-quality data to make key decisions

As an excellent candidate, you will possess…

• Ph.D. in cell or molecular biology or related field with relevant research experience in disease biology/physiology.
• Deep knowledge of cell biology/signaling and associated lab techniques.
• Experience with cell engineering is a plus.
• Strong experimental skills, especially in assay development (in vitro & in vivo models) and cell and molecular biology.
• Experience with IHC or/and basic histology, preferred but not required. 
• Expertise in mammalian cell culture techniques (3D culture experience desirable).
• Excellent communication and presentation skills for conveying complex technical information in a clear, concise, and thorough manner.
• The motivation to thrive in an entrepreneurial environment by being team-oriented and focused on execution.
• A demonstrated ability to manage multiple projects and experience working with highly technical projects and personnel.
• A demonstrated track record of being highly adaptable and responsive to technical and business opportunities and needs – comfortable delivering against challenging commitments.

Sonata Therapeutics and Flagship Pioneering are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or veteran status.