EXO Therapeutics

Principal Scientist, Biology

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, autoimmunity, inflammation and a broad range of other diseases.

Overview

Exo Therapeutics is seeking a principal scientist to work on developing novel therapeutics for autoimmunity and inflammation with opportunities to expand into other disease areas. This is a unique opportunity to lead in design, development and execution of immunological assays together with an innovative team of cross functional scientists to enable pre-clinical drug evaluation. In this role, you will apply cross-species immunology expertise to help spearhead in-vitro and ex-vivo studies to address key scientific questions on disease biology, understand responses to novel medicine and bridge gaps in translational immunology. There will be opportunities to collaborate with internal and external teams, provide hands-on guidance for junior scientists, data interpretation and presenting ideas to broader Exo teams to impact key decision making. The scientist will be expected to extend our existing technical/scientific expertise to enhance and accelerate research. We are keen to identify someone who is a self-starter and proactive and who can work independently and effectively.

Responsibilities

• Research, develop and execute novel (target-specific) immunological assays on non-clinical, primary samples to support mechanistic and translational biology efforts.
• Design, execute, and troubleshoot complex multicolor flow cytometry, ELISA methods using state-of-art instrumentation for characterizing molecules and understanding disease biology in pre-clinical studies.
• Train junior scientists with technical/scientific guidance: define scope of work, design experiments, interpret data, trouble shoot, provide next steps.
• Interpret, troubleshoot, and communicate complex data and ideas to the team and the broader organization.

• Work independently and in collaboration with cross-functional teams to achieve shared project and organizational goals.

• Collaborate with bioinformatics or data analysis teams, if necessary, to extract comprehensive insights from complex datasets.
• Serve as subject matter expert on variety of immunology needs, scientific and technical to enable in vitro and ex vivo work in support of translational pipeline.
• Serve as in-house expert in immunology platforms (eg: flow cytometry, Luminex) and analytical software (eg: FlowJo)
• Ensure accurate documentation of study activities and meticulously capturing experimental work in electronic notebooks.

• Closely interface with program co-leads and senior leaders to align with strategy, timelines, company goals and deliverables.

Required Qualifications

• PhD with a minimum of 6 years of experience in immunology or related discipline with a strong publication record. 2 years in biotech/ pharmaceutical industry.
• Advanced expertise working with primary human samples, including whole blood, serum/plasma, PBMCs
• Advanced expertise in flow cytometry (including spectral flow), ELISA, including proficiency in working with diverse instruments/configurations and designing complex panels suitable for different platforms.
• Proficiency in current immunology technologies and approaches.
• Experience in experimental immunology and a solid understanding of ex-vivo/in-vitro preclinical models of immunology.
• Excellent verbal and written communication skills in English.
• Strong scientific and technical problem-solving capabilities.
• Ability to thrive in a dynamic, fast paced, multi-disciplinary environment.

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Preferred

• General understanding of small molecule drug discovery and development.
• Formal background/training in immunology with experience in autoimmunity and inflammation.
• Demonstrated project management skills and ability to function in matrixed environment.
• Familiarity with GLP-like requirements and experience using electronic notebooks.

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.