Since 1957, Opelousas General Health System has been dedicated to the provision of quality health care through its strong commitment and high standards. Central to the success of OGHS's commitment for excellence is the presence of an outstanding and highly qualified staff of physicians, nurses, technologists and other personnel who provide professional treatment in a caring environment. Serving as the region's referral medical center, OGHS is the area's most comprehensive community health care facility offering a wide range of medical specialties and state-of-the-art technology available today.

OGHS is a 197-bed full service medical center as complete and as inclusive as any referral hospital in the state. The Main Campus, South Campus, and Sunset Campus facilities are located in St. Landry Parish which boasts a population of over 92,000. The primary service area draws from surrounding communities including: Sunset, Grand Coteau, Port Barre, Eunice, Washington, Arnaudville, Leonville, Krotz Springs, Melville, Lawtell, Palmetto, Ville Platte and Church Point. OGHS is the second largest employer in Opelousas with over 1,000 employees.

Opelousas is a great place to use your feet, whether strolling over the 19th-century brick sidewalks lining its historic district or participating in the city's deep Zydeco music tradition by dancing at a local club or festival. Opelousas is Louisiana's third-oldest city and is part of the state's Main Street Program with its downtown cluster of antique shops, boutiques and restaurants serving Cajun cuisine. Visitors can see antebellum, Victorian and early 20th-century buildings on a walk through town, including the "Hidden Capital of Louisiana," which served as the governor's mansion during the Civil War. A trip to the historic Le Vieux Village, with its 19th-century cottages, Orphan Train exhibit and Jim Bowie display about the famous one-time Opelousas resident, adds historical context to the Cajun and Creole folkways still in such vibrant evidence around the city today, while the Evangeline Downs Racetrack & Casino is among the city's newest attractions.