We are seeking a highly skilled and motivated Research Associate I-III with expertise in Organic Chemistry, Analytical Chemistry, Oligonucleotide Synthesis, and large molecule Mass Spectrometry to join our team. As a research associate you will play a crucial role in development of novel epigenetic targets and delivery of raw materials to support the expansion of our epigenetic tools and services. The primary responsibilities will include DNA/RNA synthesis and HPLC purification, and assisting in synthesizing and purifying peptides/proteins. Experience with both protein and oligonucleotide high resolution mass spectrometry is a plus.

The Research Associate is a key driver of success in driving product development and services at EpiCypher®. The position requires the employee to leverage skills in chemistry to independently support the delivery of epigenetic tools and services.

Position Responsibilities:

• Work under the supervision of the Director to design new experiments and prioritize ongoing projects based on service contracts, grant deadlines, product release schedules, customer-initiated projects, etc.
• Work expeditiously to synthesize designer histones to meet product release schedules, customer-initiated projects, etc.
• Execute routine experiments with little or no supervision.
• Work independently with the Production team to coordinate/prioritize timely synthesis and purification of designer histones and evaluate quality control specifications (including troubleshooting).
• Independently organize materials, associated documentation, data, and results for multiple ongoing projects (e.g., HPLC method development, batch sheets, analysis files, etc.).
• Analyze results and assist with troubleshooting strategies/future directions in collaboration with the Director.
• Develop a comprehensive understanding of the background, scientific rationale, and methods for projects (e.g., NCL, HNCL, HPLC, and MS method development) by reading grants, relevant papers, protocols, etc.
• Work directly with grant support, also reporting to the Grants Director.
• Generate and interpret needed data (e.g., HPLC profiles/sampling, intact mass spectra via high-resolution mass spectrometry – HRMS).

Credentials and Experience:

• Bachelor’s or Master’s degree in chemistry, chemical biology, or biochemistry.
• BS with minimum of two or more years or MS with at least one year of experience.
• Minimum one years’ experience with analytical/preparative HPLC and organic synthesis (peptide and macromolecule synthesis).
• Prior experience in a commercial setting is preferred.

Knowledge and Skills:

• Organic chemistry is required.
• High-Performance Liquid Chromatography (HPLC) is required.
• High Resolution Mass Spectroscopy (HRMS) is preferred.
• Ability to work towards specific goals under minimal to no supervision.
• Ability to rapidly gain working knowledge in new fields.
• Ability to balance multiple projects at one time.
• Ability to consistently meet deadlines.
• Ability to work in a fast-paced environment.
• Excellent communication and organization skills.
• Excellent critical thinking and troubleshooting skills.
• Works equally well individually and as part of a team.

Travel Requirements:

None

Direct Reports:

None

Physical Demands:

While performing the duties of the Research Associate – Chemistry position, the employee must be able to remain in a stationary position for prolonged periods as well as move about inside the office and lab. The employee must be able to operate a computer and necessary lab equipment. The employee must be able to position self to move objects weighing up to 10 pounds throughout the workday.

Compensation:

• Competitive salary commensurate with experience.
• Generous benefits package includes subsidized health, dental, and vision; paid vacation, sick leave, and parental leave; federal and floating holidays, mental health day; 401k matching up to 5%; professional development reimbursement; paid life insurance and stock options.

EpiCypher is focused on developing products and services in order to improve and extend human life. In this mission, we hold our core values in high regard: mutual respect, fairness, commitment to excellence, customer success, scientific advancement, effective communication, integrity, and teamwork.

EpiCypher is also developing innovative product families including nucleosomes, recombinant histone binding proteins, peptides, and affinity reagents, as well as other platforms that enable experimentation and results not previously available.

EpiCypher is committed to providing a work environment that is free from all forms of harassment, discrimination, and inequality. We provide equal employment opportunities to all employees and applications for employment without regard to race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, genetic information, protected veteran status, or any other characteristic protected by law.