The Perfect Addition to Our Team

You are a versatile, self-motivated, and eager Senior Research Associate who is looking forward to rolling up your sleeves and contributing to all aspects of the ocular pipeline here at Entrada. You look forward to supporting efforts for testing EEV, antisense oligonucleotides, small interfering ribonucleic acids, and gene editing in vivo and in vitro. You are ready to partner with drug discovery scientists as we evaluate gene targeting modalities and carry out analytical assays for functional validation both in vitro and in vivo.

The Opportunity

The Senior Research Associate, Ocular will have the opportunity to be involved in several aspects of discovery biology work, including assisting with and performing ocular injections in vivo, tissue collection and processing, and analysis of samples from in vivo, ex vivo and in vitro studies. They will be an integral part of the Ocular team, supporting the development and expansion of Entrada’s Ocular portfolio.

Responsibilities

• Perform techniques like DNA/RNA/protein extraction, RT-PCR, RT-qPCR, ddPCR, western blot, tissue embedding, sectioning, immunostaining, and imaging. 
• Maintain and culture cell lines in support to in vitro and ex vivo studies
• Develop and execute cell-based or ex-vivo assays for validating biological activity of oligonucleotide therapeutics. 
• Prepare SOPs and other reports and publications.
• Collaborate with cross-functional Discovery Teams to advance the pipeline and contribute to the completion of corporate goals.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

• Humanity - We genuinely care about patients and about one another.
• Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
• Creativity - We are creative problem solvers.
• Collaboration - We are more than the sum of our parts.
• Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

• BS with 4 years or MS with 2 years of relevant experience.
• Experience with handling rodents and perform tissue collection for in vivo studies.
• Experience in the ocular space, including ocular injection, is strongly preferred.
• Hands-on experience with in vitro assays including PCR, ddPCR, qPCR, Western blotting, and immunostaining.
• Organized and focused on moving projects forward.
• Desire to work in an innovative and collaborative environment pursuing high reward science.
• Ability to juggle and prioritize multiple responsibilities, projects, and timelines.