The Company

Dyno Therapeutics is reshaping the gene therapy landscape through AI-powered vectors. Through the application of our transformative technologies and strategic partnerships with leaders in gene therapy, we believe a future with life changing gene therapies for millions of people is within reach.

Our team includes world-class molecular and synthetic biologists, protein engineers and gene therapy scientists working alongside software engineers, data scientists, and machine learning experts to transform the landscape of available gene therapy capsids. Dyno was named Startup of the Year in 2020 by Xconomy, Endpoints 11 in 2021, and one of America's Best Startups in 2022 & 2023 by Forbes!

The Role

Research Associate - Molecular Characterization. The Characterization Team is one of Dyno's core platform teams, responsible forhigh throughput molecular characterization of AAV capsids in vivo and in vitro. The Characterization Team develops state of the art workflows, leveraging automation and developing new capabilities to accurately capture capsid tropism at scale. Under the guidance of senior research staff, you will be involved in the extraction and purification of nucleic acids from mammalian cells and tissues, followed by detailed molecular analysis prior to high-throughput sequencing.

How You Will Contribute

As a Research Associate - Molecular Characterization, you will use your molecular biology skills to execute the workflows and protocols which are fundamental to the Characterization Team function. You will also learn and execute new assays as the need arises. Your work in this role will be in collaboration with other research associates, scientists, engineers and computational biologists throughout Dyno. You will have the opportunity to learn from and contribute to a diverse set of projects. You will be responsible for understanding project goals and for creatively optimizing solutions to ensure their success.

Responsibilities:

• Assist in sample inventory and dissection of tissues (mammalian cells, non-human primate and mouse tissues)
• Extract, purify, and enrich nucleic acids from mammalian cells and tissues
• Run quantification assays on purified nucleic acids (e.g., qPCR, RT-qPCR)
• Perform next-generation sequencing library preparations (amplicon sequencing) and associated QC steps
• Record sample information and experimental procedures using Dyno's LIMS system
• Assist in lab organization, including ordering supplies and restocking
• Follow lab protocols and safety regulations

Who you are

• Trusted partner
• Team oriented
• Thoughtful & detail oriented
• Work with a sense of urgency
• Appreciation for opportunities at the intersections of data science and biology

Basic qualifications

• BA or MA in biology, biochemistry, biomedical engineering, or related fields
• 2 years hands-on wet lab experience
• Experience in DNA/RNA purification and analysis protocols (qPCR, RT-qPCR, etc.)
• Molecular biology proficiency (PCR, agarose gel electrophoresis and imaging, gel excision and purification)
• Experience in tissue handling and mammalian cell culture
• Ability to follow advanced protocols and procedures
• Ability to document and maintain an organized account of lab work and results

Preferred qualifications

• Next-generation sequencing library preparation
• Focused experience in tissue processing
• Familiarity with ELN-LIMS data management software (e.g. Benchling)

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Job Type: Full-time