Occupational Summary:

A postdoctoral position is available in the Conejo-Garcia laboratory at Duke Medical School. We are seeking a highly motivated and collaborative postdoctoral fellow who has a background in Immuno-Oncology, and/or KRAS targeting, with a strong interest in Immunology research. The postdoc will work on how inhibiting oncogenic signals in different human tumors, using complementary interventions, influences the tumor immuno-environment and synergizes with anti-cancer immunotherapies. These approaches will be complemented with the generation of novel recombinant antibodies targeting specific intracellular antigens, based on recent articles published by the lab (PMID: 33536615, 37909039, 34949671).

Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, the Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health. a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

Please, submit a C.V. (Curriculum Vitae) including publication list, along with contact information of three references, to jose.conejo-garcia@duke.edu

Work Performed:

• Develop in vivo models of different oncogene-driven tumors, to characterize the anti-tumor immune response upon inhibition of oncogenic signals, and the best way of coordinating these responses with existing and novel immunotherapies. (40%):

• Generate novel recombinant tumor cell-penetrating antibodies targeting intracellular targets and characterize their activity in vitro and in vivo.(40%)

• Write manuscripts and fellowship applications, and present data at national meetings (10%):

• Training of undergraduate and graduate students, participation in department activities (10%)

Required Qualifications at this Level:

Education/Training

Self-motivated individuals with a PhD in 2024

Experience

The ideal candidates should have a strong background in immunology and human cancer

Additional expertise in the generation of pharmacological inhibitors or antibodies is greatly advantageous

Skills

Candidates will develop skills in mouse models of cancer, immune function assays, flow cytometry, microscopy, biochemistry and molecular biology techniques